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Table 2 Associations (FDR p < 0.05) between individual CpG sites (age 7, n = 453,723) and the early life growth in models

From: Childhood DNA methylation as a marker of early life rapid weight gain and subsequent overweight

Exposure n CpG name Nearest gene Gene region CpG island name Model Coef SE P PFDR
With cell counts
RWG 116 cg01379158 NT5M TSS200 chr17:17,206,527–17,207,306 ISVA 0.011 0.0018 2.91 × 10–7 0.02
Without cell counts
RWG 125 cg01379158 NT5M TSS200 chr17:17,206,527–17,207,306 ISVA 0.011 0.0017 1.41 × 10–8 0.01
RWG 125 cg11531579 CHFR Island chr12:133,484,658–133,485,739 SVA 0.011 0.0019 4.16 × 10–8 0.02
RWG 125 cg11531579 CHFR Island chr12:133,484,658–133,485,739 ISVA 0.011 0.0019 1.26 × 10–7 0.03
  1. All associations FDR p < 0.05 are presented from the ISVA and SVA models, and the models with and without adjustment for cell types. Chr, chromosome; PFDR, FDR p value; P, unadjusted p value, Coef, coefficient; TSS200, transcription start site; RWG, rapid weight gain; SVA, Surrogate variable analysis, and ISVA, independent surrogate variable analysis. Bonferroni p value threshold = 1.04 × 10–7