Childhood DNA methylation as a marker of early life rapid weight gain and subsequent overweight

Clinical Epigenetics

Table 2 Associations (FDR p < 0.05) between individual CpG sites (age 7, n = 453,723) and the early life growth in models

Exposure	n	CpG name	Nearest gene	Gene region	CpG island name	Model	Coef	SE	P	P_FDR
With cell counts
RWG	116	cg01379158	NT5M	TSS200	chr17:17,206,527–17,207,306	ISVA	0.011	0.0018	2.91 × 10^–7	0.02
Without cell counts
RWG	125	cg01379158	NT5M	TSS200	chr17:17,206,527–17,207,306	ISVA	0.011	0.0017	1.41 × 10^–8	0.01
RWG	125	cg11531579	CHFR	Island	chr12:133,484,658–133,485,739	SVA	0.011	0.0019	4.16 × 10^–8	0.02
RWG	125	cg11531579	CHFR	Island	chr12:133,484,658–133,485,739	ISVA	0.011	0.0019	1.26 × 10^–7	0.03

All associations FDR p < 0.05 are presented from the ISVA and SVA models, and the models with and without adjustment for cell types. Chr, chromosome; P_FDR, FDR p value; P, unadjusted p value, Coef, coefficient; TSS200, transcription start site; RWG, rapid weight gain; SVA, Surrogate variable analysis, and ISVA, independent surrogate variable analysis. Bonferroni p value threshold = 1.04 × 10^–7

ISSN: 1868-7083