Gene expressiona | Trait | DNA methylationb | eQTMc |
|---|
ProbeID | Effect | P value | CpG | Effect | P value | Coeff | P value |
|---|
ILMN_1779324 (GZMA) | 1.0033 | 6.01E−08 | TG | cg04716530 | − 0.0122 | 3.58E−05 | − 11.7641 | 6.91E−12 |
ILMN_2352563 (CLDND1) | 0.4003 | 6.52E−05 | TG | cg21566642 | − 0.0215 | 1.91E−05 | − 5.1957 | 3.54E−19 |
ILMN_1671891 (PID1) | − 0.0425 | 7.23E−09 | BMI | cg03636183 | 0.0016 | 3.04E−05 | − 3.9797 | 1.28E−11 |
ILMN_1773650 (LRRN3) | − 0.0669 | 3.77E−05 | BMI | cg03636183 | 0.0016 | 3.04E−05 | − 16.4622 | 3.46E−41 |
|  |  |  |  | cg06096336 | 0.0017 | 9.51E−07 | − 15.0031 | 2.91E−24 |
|  |  |  |  | cg13708645 | 0.0015 | 6.72E−07 | − 9.5025 | 2.31E−09 |
|  |  |  |  | cg17287155 | 0.0012 | 8.69E−06 | − 26.2306 | 3.09E−54 |
|  |  |  |  | cg25649826 | 0.0009 | 1.63E−05 | − 14.4989 | 3.43E−08 |
|  |  |  |  | cg26361535 | 0.0016 | 1.85E−07 | − 12.549 | 2.30E - 11 |
ILMN_2048591 ( LRRN3) | − 0.0604 | 1.46E−05 | BMI | cg03636183 | 0.0016 | 3.04E−05 | − 14.4435 | 2.67E−43 |
|  |  |  |  | cg06096336 | 0.0017 | 9.51E−07 | − 11.5428 | 1.40E−19 |
|  |  |  |  | cg13708645 | 0.0015 | 6.72E−07 | − 8.2627 | 1.36E−09 |
|  |  |  |  | cg17287155 | 0.0012 | 8.69E−06 | − 21.4408 | 1.19E−48 |
- The table shows an overview of the overlap of the hits with nominal significant (P < 0.05) replication in KORA in all three association analyses, including the association between (1) DNA methylation and cardio-metabolic traits, (2) gene expression and cardio-metabolic traits, and (3) the eQTM results for the gene and CpG that are associated with the same cardio-metabolic trait
- P value thresholds in the discovery for DNA methylation P < 4.08 × 10–5 (0.05/1224), gene expression P < 2.25 × 10–4 (0.05/200) and for eQTM P < 4.4 × 10–8 (0.05/443 × 2549)
- P value thresholds in the replication for TG; gene expression P < 3.33 × 10–3 (0.05/15), DNA methylation P < 1.43 × 10–3 (0.05/35), and BMI; gene expression
- P < 3.13 × 10–3 (0.05/16), DNA methylation P < 3.13 × 10–3 (0.05/16), and eQTM P < 2.04 × 10–7 (0.05/1224 × 200)
- Results that are presented underlined passed the replication P value threshold in the KORA study
- TG triglycerides, BMI body mass index
- aExpression probe ~ cardio-metabolic trait + age, sex, cell count, RNA quality score, technical covariates, BMI and relevant medication
- bCpGs ~ cardio-metabolic trait + age, sex, cell count, technical covariates, BMI and relevant medication
- cExpression probe ~ CpGs + age, sex
