|
CpG
|
Chr:positiona
|
Gene IDb
|
Trait
|
Model 1
|
Model 2
|
Replication
|
|---|
|
Effect
|
P value
|
Effect
|
P value
|
Effect
|
P value
|
|---|
|
cg04716530
|
16:30485684
|
ITGAL
|
HDL
|
0.01700
|
2.02E−07
|
0.01550
|
6.34E−06
|
0.00014
|
9.82E−04
|
|
cg07826859
|
7:45020086
|
MYO1G
|
HDL
|
0.01440
|
6.79E−06
|
0.01390
|
3.61E−05
|
0.00018
|
1.61E−03
|
|
cg26724967
|
16:3115223
|
IL32
|
HDL
|
0.01290
|
2.89E−06
|
0.01220
|
2.34E−05
|
0.00015
|
1.63E−03
|
|
cg16391678
|
16:30485597
|
ITGAL
|
HDL
|
0.01520
|
1.03E−06
|
0.01400
|
1.60E−05
|
0.00013
|
5.14E−03
|
|
cg16519923
|
16:30485810
|
ITGAL
|
HDL
|
0.01980
|
8.23E−08
|
0.01790
|
3.44E−06
|
0.00012
|
9.75E−03
|
|
cg10310310
|
7:157367150
|
PTPRN2;MIR153-2
|
HDL
|
0.01130
|
4.49E−06
|
0.01060
|
4.05E−05
|
0.00011
|
1.96E−02
|
|
cg24323726
|
3:111314186
|
ZBED2;CD96
|
HDL
|
0.01300
|
4.84E−07
|
0.01230
|
5.32E−06
|
0.00009
|
3.41E−02
|
|
cg07929642
|
16:89390685
|
ANKRD11
|
HDL
|
0.01650
|
1.87E−07
|
0.01550
|
3.13E−06
|
0.00009
|
4.25E−02
|
|
cg21566642
|
2:233284661
|
–
|
TG
|
− 0.01990
|
3.89E−05
|
− 0.02150
|
1.91E−05
|
− 0.01967
|
1.14E−05
|
|
cg04716530
|
16:30485684
|
ITGAL
|
TG
|
− 0.01370
|
1.23E−06
|
−0.01220
|
3.58E−05
|
−0.00380
|
5.34E−04
|
|
cg27409015
|
2:158114424
|
GALNT5
|
TG
|
0.01660
|
8.39E−07
|
0.01490
|
2.16E−05
|
0.00683
|
1.50E−03
|
|
cg06635952
|
2:70025869
|
ANXA4
|
TG
|
0.01300
|
9.06E−07
|
0.01280
|
3.36E−06
|
0.00502
|
5.95E−03
|
|
cg11095027
|
11:1297066
|
TOLLIP
|
TG
|
0.00996
|
2.72E−05
|
0.01040
|
2.64E−05
|
0.00375
|
7.82E−03
|
|
cg26219092
|
8:134388022
|
–
|
TG
|
0.01050
|
2.37E−06
|
0.00991
|
2.05E−05
|
0.00285
|
1.73E−02
|
|
cg10919522
|
14:74227441
|
C14orf43
|
TG
|
− 0.01410
|
7.90E−09
|
− 0.01260
|
7.97E−07
|
− 0.00491
|
1.91E−02
|
|
cg22635096
|
21:46550644
|
ADARB1
|
TG
|
0.01370
|
6.61E−08
|
0.01300
|
8.65E−07
|
0.00392
|
3.55E−02
|
|
cg00310412
|
15:74724918
|
SEMA7A
|
WHR
|
− 0.05000
|
3.96E−05
|
− 0.07150
|
1.95E−07
|
− 0.06952
|
4.54E−05
|
|
cg04424621
|
6:27101941
|
HIST1H2BJ
|
WHR
|
− 0.06490
|
1.06E−05
|
− 0.07360
|
1.03E−05
|
− 0.07191
|
5.73E−05
|
|
cg04583842
|
16:88103117
|
BANP
|
WHR
|
0.12600
|
5.29E−08
|
0.12500
|
1.56E−06
|
0.06802
|
3.71E−03
|
|
cg13755776
|
11:3602845
|
–
|
WHR
|
− 0.08530
|
1.03E−06
|
− 0.08200
|
3.33E−05
|
− 0.04521
|
3.71E−02
|
|
cg17287155
|
5:393347
|
AHRR
|
BMI
|
0.00117
|
8.69E−06
|
NA
|
NA
|
0.00053
|
3.11E−06
|
|
cg26361535
|
8:144576604
|
ZC3H3
|
BMI
|
0.00155
|
1.85E−07
|
NA
|
NA
|
0.00102
|
2.38E−05
|
|
cg06096336
|
2:231989800
|
PSMD1;HTR2B
|
BMI
|
0.00168
|
9.51E−07
|
NA
|
NA
|
0.00111
|
1.66E−04
|
|
cg13708645
|
12:121974305
|
KDM2B
|
BMI
|
0.00152
|
6.72E−07
|
NA
|
NA
|
0.00089
|
1.01E−03
|
|
cg25649826
|
17:20938740
|
USP22
|
BMI
|
0.00086
|
1.63E−05
|
NA
|
NA
|
0.00041
|
3.15E−03
|
|
cg24539517
|
10:121161258
|
GRK5
|
BMI
|
0.00149
|
2.95E−05
|
NA
|
NA
|
0.00078
|
4.33E-03
|
|
cg03636183
|
19:17000585
|
F2RL3
|
BMI
|
0.00160
|
3.04E−05
|
NA
|
NA
|
0.00063
|
3.40E−02
|
- The table shows 26 CpGs that are associated to at least one cardio-metabolic trait and in eQTM with at least one smoking-related gene-expression probe
- Only CpGs significantly associated in both models and nominally significant (P < 0.05) in the replication are presented in this table
- HDL high-density lipoprotein, TG triglycerides, WHR waist to hip ratio, BMI body mass index, NA not applicable (because of adjusting for BMI)
- Model 1: Adjusted for age, sex, cell count, and technical covariates. Model 2: Model 1 + BMI and relevant medication
- We did not correct for additional covariates when testing the association for BMI
- P value threshold for discovery P < 4.08 × 10–5 (0.05/1224)
- P value threshold for replication: HDL, P < 8.62 × 10–4 (0.05/58); TG, P < 1.43 × 10–3 (0.05/35); WHR, P < 8.33 × 10–3 (0.05/6); BMI, P < 3.13 × 10–3 (0.05/16)
- CpGs that are presented underlined passed the replication P value threshold in 1727 participants of the KORA study
- aGenome coordinates provided by Illumina (GRCh37/hg19)
- bAccording to the Illumina Infinium HumanMethylation450K annotation file
