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Table 1 Population characteristics

From: Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits

  Discovery dataset Replication dataset
Gene expression data set DNA methylation data set Gene expression data set DNA methylation data set
N 716 1412 687 1727
Female 389 (54.3%) 791 (56.0%) 339 (49.3%) 882 (51.0%)
Age (years) 59.8 (± 8.1) 63.6 (± 8.1) 69.1 (± 4.4) 61.0 (± 8.8)
BMI (kg/m2) 27.6 (± 4.6) 27.7 (± 4.4) 28.9 (± 4.5) 28.1 (± 4.8)
WHR 0.9 (± 0.1) 0.9 (± 0.1) 0.9 (± 0.1) 0.9 (± 0.1)
Current smokers 193 (27.0%) 266 (18.0%) 53 (7.7%) 250 (14.5%)
Triglycerides (mmol/L) 1.5 (± 0.9) 1.5 (± 0.8) 1.5 (± 0.9) 1.5 (± 1.1)
HDL-cholesterol (mmol/L) 1.4 (± 0.4) 1.5 (± 0.4) 1.4 (± 0.4) 1.5 (± 0.4)
LDL-cholesterol (mmol/L) 3.9 (± 1.0) 3.8 (± 1.0) 3.7 (± 0.9) 3.6 (± 0.9)
Total cholesterol (mmol/L) 5.6 (± 1.1) 5.5 (± 1.0) 5.8 (± 1.0) 5.7 (± 1.0)
Lipid lowering medication (yes) 190 (26.5%) 404 (28.6%) 172 (25.0%) 283 (16.4%)
Systolic blood pressure (mm Hg) 134.2 (± 19.8) 139.5 (± 21.5) 128.7 (± 19.4) 124.8 (± 18.7)
Diastolic blood pressure (mm Hg) 82.8 (± 11.4) 83.6 (± 11.5) 74.7 (± 10.0) 76.1 (± 10.0)
Anti-hypertensive medication (yes) 215 (30.0%) 517 (36.6%) 383 (55.7%) 650 (37.6%)
Glucose (mmol/L) 5.6 (± 1.0) 5.6 (± 1.1) NA NA
Insulin (pmol/L) 96.0 (± 63.0) 89.3 (± 56.6) 88.2 (± 122.0) 81.3 (± 91.0)
Anti-diabetic medication (yes) 39 (5.4%) 95 (6.7%) 76 (11.1%) 134 (7.8%)
  1. Values are presented as mean ± (SD) or N (%)
  2. BMI body mass index, WHR waist to hip ratio, HDL high-density lipoproteins, LDL low-density lipoprotein
  3. The participants included in the gene expression data are a subset of the total DNA methylation dataset
  4. NA not applicable; the associations with glucose levels in model 2 from the discovery did not pass the significance threshold