Table 1 Population characteristics
Discovery dataset | Replication dataset | |||
|---|---|---|---|---|
Gene expression data set | DNA methylation data set | Gene expression data set | DNA methylation data set | |
N | 716 | 1412 | 687 | 1727 |
Female | 389 (54.3%) | 791 (56.0%) | 339 (49.3%) | 882 (51.0%) |
Age (years) | 59.8 (± 8.1) | 63.6 (± 8.1) | 69.1 (± 4.4) | 61.0 (± 8.8) |
BMI (kg/m2) | 27.6 (± 4.6) | 27.7 (± 4.4) | 28.9 (± 4.5) | 28.1 (± 4.8) |
WHR | 0.9 (± 0.1) | 0.9 (± 0.1) | 0.9 (± 0.1) | 0.9 (± 0.1) |
Current smokers | 193 (27.0%) | 266 (18.0%) | 53 (7.7%) | 250 (14.5%) |
Triglycerides (mmol/L) | 1.5 (± 0.9) | 1.5 (± 0.8) | 1.5 (± 0.9) | 1.5 (± 1.1) |
HDL-cholesterol (mmol/L) | 1.4 (± 0.4) | 1.5 (± 0.4) | 1.4 (± 0.4) | 1.5 (± 0.4) |
LDL-cholesterol (mmol/L) | 3.9 (± 1.0) | 3.8 (± 1.0) | 3.7 (± 0.9) | 3.6 (± 0.9) |
Total cholesterol (mmol/L) | 5.6 (± 1.1) | 5.5 (± 1.0) | 5.8 (± 1.0) | 5.7 (± 1.0) |
Lipid lowering medication (yes) | 190 (26.5%) | 404 (28.6%) | 172 (25.0%) | 283 (16.4%) |
Systolic blood pressure (mm Hg) | 134.2 (± 19.8) | 139.5 (± 21.5) | 128.7 (± 19.4) | 124.8 (± 18.7) |
Diastolic blood pressure (mm Hg) | 82.8 (± 11.4) | 83.6 (± 11.5) | 74.7 (± 10.0) | 76.1 (± 10.0) |
Anti-hypertensive medication (yes) | 215 (30.0%) | 517 (36.6%) | 383 (55.7%) | 650 (37.6%) |
Glucose (mmol/L) | 5.6 (± 1.0) | 5.6 (± 1.1) | NA | NA |
Insulin (pmol/L) | 96.0 (± 63.0) | 89.3 (± 56.6) | 88.2 (± 122.0) | 81.3 (± 91.0) |
Anti-diabetic medication (yes) | 39 (5.4%) | 95 (6.7%) | 76 (11.1%) | 134 (7.8%) |