Genetic and environmental causes of variation in epigenetic aging across the lifespan

Li, Shuai; Nguyen, Tuong L.; Wong, Ee Ming; Dugué, Pierre-Antoine; Dite, Gillian S.; Armstrong, Nicola J.; Craig, Jeffrey M.; Mather, Karen A.; Sachdev, Perminder S.; Saffery, Richard; Sung, Joohon; Tan, Qihua; Thalamuthu, Anbupalam; Milne, Roger L.; Giles, Graham G.; Southey, Melissa C.; Hopper, John L.

doi:10.1186/s13148-020-00950-1

Clinical Epigenetics

Table 2 Within-study familial correlations in DNAm age

From: Genetic and environmental causes of variation in epigenetic aging across the lifespan

Study^a	Type of pairs	Number of pairs	Mean age	Correlation (95% CI)	P	P for MZ versus DZ
PETS EPIC	MZ	23	0	0.18 (− 0.28 to 0.57)	0.45	0.57
	DZ	22	0	0.01 (− 0.35 to 0.36)	0.98
	MZ and DZ	45	0	0.15 (− 0.22 to 0.34)	0.64
PETS 27K	MZ	22	0	0.35 (− 0.04 to 0.64)	0.85	0.69
	DZ	11	0	0.00 (− 0.46 to 0.46)	0.09
	MZ and DZ	33	0	0.18 (− 0.15 to 0.47)	0.76
PETS 450K birth	MZ	9	0	− 0.05 (− 0.51 to 0.43)	0.09	0.29
	DZ	5	0	0.62 (0.01 to 0.89)	0.99
	MZ and DZ	14	0	− 0.08 (− 0.54 to 0.41)	0.29
PETS 450K 18 months	MZ	6	1.5	− 0.06 (− 0.62 to 0.55)	0.87	0.58
	DZ	4	1.5	− 0.52 (− 0.91 to 0.40)	0.31
	MZ and DZ	10	1.5	− 0.12 (− 0.62 to 0.46)	0.71
BSGS	MZ	67	13.8	0.69 (0.63 to 0.74)	< 0.001	< 0.001
	DZ	111	13.2	0.35 (0.20 to 0.48)	< 0.001
	Siblings	260	14.0	0.32 (0.20 to 0.42)	< 0.001
	Parent–offspring	363	13.4	0.15 (0.02 to 0.27)	0.02
	Spouses	59	46.6	− 0.01 (− 0.25 to 0.24)	0.96
E-Risk	MZ	426	18.0	0.46 (0.40 to 0.52)	< 0.001	0.28
	DZ	306	18.0	0.40 (0.33 to 0.47)	< 0.001
	MZ and DZ	732	18.0	0.43 (0.39 to 0.48)	< 0.001
DTR younger adults	MZ	73	33.1	0.62 (0.52 to 0.70)	< 0.001	−
AMDTSS	MZ	66	55.6	0.43 (0.26 to 0.58)	< 0.001	0.20
	DZ	66	57.0	0.24 (0.04 to 0.42)	0.02
	MZ and DZ	132	56.3	0.32 (0.18 to 0.45)	< 0.001
	Siblings	552	56.4	0.12 (0.02 to 0.22)	0.02
TwinsUK	MZ	33	55.3	0.23 (− 0.03 to 0.46)	0.09	0.41
	DZ	43	59.2	0.04 (− 0.33 to 0.39)	0.85
	MZ and DZ	76	57.5	0.12 (− 0.07 to 0.37)	0.17
MuTHER	MZ	93	58.4	0.54 (0.44 to 0.63)	< 0.001	0.08
	DZ	153	56.6	0.37 (0.25 to 0.48)	< 0.001
	MZ and DZ	246	57.3	0.44 (0.36 to 0.52)	< 0.001
DTR older adults	MZ	77	63.2	0.55 (0.43 to 0.65)	< 0.001	−
OATS	MZ	108	71.2	0.40 (0.26 to 0.53)	< 0.001	−
LSADT 1997	MZ	18	76.3	0.04 (− 0.66 to 0.70)	0.93	0.36
	DZ	25	76.2	0.39 (0.14 to 0.60)	< 0.001
	MZ and DZ	43	76.2	0.34 (0.09 to 0.55)	0.01
LSADT 2007	MZ	18	86.2	0.41 (0.05 to 0.68)	0.04	0.95
	DZ	25	86.1	0.40 (0.11 to 0.62)	0.01
	MZ and DZ	43	86.1	0.40 (0.17 to 0.59)	< 0.001
MCCS	Spouses	62	60.1	0.12 (− 0.12 to 0.35)	0.33	−

MZ monozygotic twin, DZ dizygotic twin, CI confidence interval
^aStudies—PETS Peri/postnatal Epigenetic Twins Study, including three datasets measured using the 27K array, 450K array (at two points: at birth and age 18 months), and EPIC array, respectively; BSGS Brisbane System Genetics Study; E-Risk Environmental Risk Longitudinal Twin Study, DTR Danish Twin Registry, in two groups: younger and older adults, AMDTSS Australian Mammographic Density Twins and Sisters Study, MuTHER Multiple Tissue Human Expression Resource Study, OATS Older Australian Twins Study, LSADT Longitudinal Study of Aging Danish Twins, with samples collected at years 1997 and 2007, respectively, MCCS Melbourne Collaborative Cohort Study

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ISSN: 1868-7083

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