Skip to main content
Fig. 1 | Clinical Epigenetics

Fig. 1

From: Genome-wide methylation analysis in Silver–Russell syndrome, Temple syndrome, and Prader–Willi syndrome

Fig. 1

a Methylation status of MLID patients focusing on 50 known iDMRs including at least four probes. Red and blue boxes indicate the iDMRs contained more than two consecutive probes showing hypermethylation (red) or hypomethylation (blue). b Methylation indices (%) for CpGs at additionally affected iDMRs in each MLID patient determined by pyrosequencing analysis. SRS Pt. 1 and TS14 Pt. 2 are not included due to lack of remaining samples. Median and normal ranges are calculated using the results of 50 healthy controls. The hypomethylated CpG sites are highlighted with light gray backgrounds. *1–9 are CpG sites that have also been examined by the HM450k (*1cg19079047, *2cg02965180, *3cg05277165, *4cg19344806, *5cg23714917, *6cg21200654, *7cg11826663, *8cg24785225, *9cg10271763). chr chromosome, iDMRs imprinting-associated differentially methylated regions, SRS Silver–Russell syndrome, TS14 Temple syndrome, PWS Prader–Willi syndrome, MLID multilocus imprinting disturbance, HM450k HumanMethylation450 BeadChip

Back to article page