Fig. 1

DMP associations with diagnosis and pathology. The methylation level as measured by B value for probe cg14058329 annotated to HOXA5 was plotted again AD diagnosis (a) and Braak stage (b). Similarly, B value for probe cg09448088 annotated to MCF2L was plotted again diagnosis (c) and Braak stage (d). In both cases, hypermethylation was observed in later Braak stage than earlier stage