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Fig. 2 | Clinical Epigenetics

Fig. 2

From: BET protein inhibitor apabetalone (RVX-208) suppresses pro-inflammatory hyper-activation of monocytes from patients with cardiovascular disease and type 2 diabetes

Fig. 2

Monocytes from DM2 + CVD patients and control subjects exhibit differential gene expression that is inhibited by 25 μM apabetalone (Apa). a Pro-inflammatory genes that show elevated expression in DM2 + CVD monocytes as compared to controls. b. Genes that show reduced expression in DM2 + CVD monocytes as compared to controls. Gene expression is expressed as endogenous control-normalized counts (NanoString™). Statistics: 2-Way repeated measures ANOVA followed by Tukey’s multiple comparisons correction for within-group comparisons, or Bonferroni’s test for between-group comparisons; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; ns, non-significant. Individual patient data are shown as a mean ± SEM

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Clinical Epigenetics

ISSN: 1868-7083

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