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Table 4 CpG-specific associations between DNAm with BPD, SBI, INF and ROP (all were included in the model) while adjusting for gestational age at birth (weeks), sex, whether the infant was outborn, the proportion of epithelial cells, recruitment site, batch, and PMA (weeks) where appropriate; the beta coefficient represents the average difference in DNA methylation for infants that experienced that morbidity in the NICU, relative to those that did not, while adjusting for the other health complications included in the neonatal morbidity risk score

From: Serious neonatal morbidities are associated with differences in DNA methylation among very preterm infants

CpG

Gene

BPD

SBI

INF

ROP

Coef

p value

Coef

p value

Coef

p value

Coef

p value

cg06343740

HPS4;SRRD

0.0111

2.30E−03

0.0098

4.01E−02

0.0131

4.81E−03

0.0083

3.91E−01

cg07846767

FGFR1OP

0.0228

1.03E−03

0.0346

9.64E−05

0.0218

1.03E−02

0.0037

7.88E−01

cg08303167

6q22.33

0.0320

9.73E−04

0.0078

4.96E−01

0.0349

1.24E−03

0.0261

9.39E−02

cg09787236

6q13

0.0320

1.41E−04

0.0315

6.90E−03

0.0296

1.99E−03

0.0012

9.57E−01

cg11255857

TNS3

0.0257

4.15E−05

0.0229

4.97E−03

0.0127

1.08E−01

− 0.0021

8.89E−01

cg12861771

TMEM266

− 0.0171

3.26E−05

− 0.0118

4.22E−02

− 0.0162

4.89E−04

0.0040

7.33E−01

cg16636226

LRRC3B

0.0235

4.06E−03

0.0076

5.11E−01

0.0332

2.50E−04

0.0414

1.62E−03

cg20938154

ZNF780A

− 0.0130

9.11E−07

− 0.0057

9.00E−02

− 0.0025

4.37E−01

− 0.0081

8.00E−02

cg24517837

TENM2

0.0302

2.97E−03

0.0120

3.25E−01

0.0486

3.11E−05

0.0331

4.73E−02

cg26838315

10q21.1

0.0532

3.00E−04

0.0303

3.47E−02

0.0547

1.69E−04

0.0093

6.69E−01

  1. CpG cytosine-phosphate-guanine site, Coef. estimated difference in DNAm associated with the presence of each neonatal morbidities, BPD Bronchopulmonary dysplasia, INF neonatal infection, SBI serious brain injury, ROP severe retinopathy of prematurity