Serious neonatal morbidities are associated with differences in DNA methylation among very preterm infants

Clinical Epigenetics

Table 3 Differentially methylated regions (DMRs) containing at least two CpGs, with an estimated regional change in DNAm of at least 1% for each increase in the neonatal morbidity risk score and yielding a DMR p value < 0.0001

DMR	# CpGs	Coef	Std. Err	p value	Gene	Region
chr2:127822822–127823595	2	− 0.0098	0.0019	2.30E−07	BIN1	Body
chr20:44636682–44636831	2	0.0119	0.0024	3.86E−07	MMP9	TSS1500
chr12:4489056–4489155	3	0.0145	0.0029	4.16E−07	FGF23	TSS200;TSS1500
chr8:70360215–70361190	5	0.0077	0.0015	5.69E−07	LINC01603	Body;TSS200;TSS1500
chr13:95358540–95358924	2	− 0.0140	0.0029	1.89E−06	–	–
chr10:8094142–8094482	3	0.0107	0.0024	1.05E−05	FLJ45983	Body
chr3:142956052–142956059	2	0.0091	0.0021	1.55E−05	–	–

DMR differentially methylated region, Coef. estimated difference in DNAm associated with an increase of one in the neonatal morbidity risk score, Std. Err. standard error

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