Skip to main content

Table 1 H3S10 kinases and their H3S10ph-related function in oncogenesis

From: Rebelled epigenome: histone H3S10 phosphorylation and H3S10 kinases in cancer biology and therapy

Kinase H3S10-specific consequences of activity in oncogenesis and in cancer cells
AURKA Role in mitotic chromosome condensation. Inhibition facilitates leukemia cell differentiation [91, 92]
AURKB Role in mitotic division [142]
IKKα NF-κB, inflammation, immune-response [129,130,131, 143]
JNK Certain oncogenes activation through H3S10ph in their promoters in response to oncogenic stimuli [98, 99, 110]
AKT1 Potential role in gene expression activation in response to oncogenic compounds together with RSK2 [144]
MAP3K8 Activation of IEG/oncogene-FOS and cellular transformation in response to DNA damage [145]
CDK8 Activation of IEGs/oncogenes [111, 112]; downregulation of superenhancer-dependent genes in acute myeloid leukemia [118]
MSK1/2 Activation of IEGs/oncogenes FOS and JUN [7, 12]; response to carcinogens [16, 64, 100]; inflammation [134, 135]
PIM1 Activation of proto-oncogene FOSL1 [63]; oncogenic miR-17-92 [146] cooperation with MYC to induce cellular transformation [62, 63]; potential role in mitotic checkpoint regulation [147, 148]