Table 1 H3S10 kinases and their H3S10ph-related function in oncogenesis
From: Rebelled epigenome: histone H3S10 phosphorylation and H3S10 kinases in cancer biology and therapy
Kinase | H3S10-specific consequences of activity in oncogenesis and in cancer cells |
|---|---|
AURKA | Role in mitotic chromosome condensation. Inhibition facilitates leukemia cell differentiation [91, 92] |
AURKB | Role in mitotic division [142] |
IKKα | |
JNK | Certain oncogenes activation through H3S10ph in their promoters in response to oncogenic stimuli [98, 99, 110] |
AKT1 | Potential role in gene expression activation in response to oncogenic compounds together with RSK2 [144] |
MAP3K8 | Activation of IEG/oncogene-FOS and cellular transformation in response to DNA damage [145] |
CDK8 | Activation of IEGs/oncogenes [111, 112]; downregulation of superenhancer-dependent genes in acute myeloid leukemia [118] |
MSK1/2 | Activation of IEGs/oncogenes FOS and JUN [7, 12]; response to carcinogens [16, 64, 100]; inflammation [134, 135] |
PIM1 | Activation of proto-oncogene FOSL1 [63]; oncogenic miR-17-92 [146] cooperation with MYC to induce cellular transformation [62, 63]; potential role in mitotic checkpoint regulation [147, 148] |