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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Leveraging locus-specific epigenetic heterogeneity to improve the performance of blood-based DNA methylation biomarkers

Fig. 5

Counts of endometrioid (n = 9) or serous (n = 14) EOC subtype patient plasma samples from the validation cohort above the CA-125 cutoff (35 U/ml) or EpiClass cutoffs derived from the training cohort. Numbers above each bar indicate the number of samples above each given classification cutoff. Mean* methylation was inferred from the fraction of all methylated epialleles. MSP* performance estimated using an MDC of 95%. No available specificity measurements for CA-125 as the control samples (n = 12) did not have measured CA-125 U/mL concentrations. MDC methylation density cutoff

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