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Table 4 Associations between age acceleration and lifestyle factors in middle-age group

From: The influences of DNA methylation and epigenetic clocks, on metabolic disease, in middle-aged Koreans

  AgeAccelGrim   DNAmPAI1AdjAge  
Factors Estimate (S.E) p value Estimate (S.E) p value
Fasting glucose (mg/dl) 2.31(1.15) 0.045 15.49(3.71) <0.001
HDL (mg/dl) -0.28(0.24) 0.248 -39.44(18.58) 0.035
Waist circumference (cm) 0.05(0.16) 0.734 75.98(28.48) 0.008
Triglyceride (mg/dl) -1.15(3.23) 0.722 0.98(1.40) 0.488
SBP (mmHg) 0.12(0.25) 0.622 32.70(17.79) 0.070
DBP (mmHg) 0.13(0.16) 0.432 49.45(28.19) 0.081
Abdominal fat (%) 0.0009(0.0008) 0.261 12133.46(5445.95) 0.027
Body fat (kg) 0.05(0.10) 0.594 87.27(45.71) 0.058
Body fat (%) 0.08(0.10) 0.395 85.12(47.94) 0.078
BMI (m2/kg) 0.04(0.06) 0.482 182.58(77.65) 0.020
  1. Data are presented as estimates [standard error]. Estimate, difference in factor per year of epigenetic age acceleration. Chronological age, sex, and regional area were included in multiple linear regression. AgeAccelGrim DNAm GrimAge Acceleration, DNAmPAI1AdjAge age-adjusted DNAmPAI1, HDL high-density lipoprotein, SBP systolic blood pressure, DBP diastolic blood pressure, BMI body mass index