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Table 4 Associations between age acceleration and lifestyle factors in middle-age group

From: The influences of DNA methylation and epigenetic clocks, on metabolic disease, in middle-aged Koreans

 

AgeAccelGrim

 

DNAmPAI1AdjAge

 

Factors

Estimate (S.E)

p value

Estimate (S.E)

p value

Fasting glucose (mg/dl)

2.31(1.15)

0.045

15.49(3.71)

<0.001

HDL (mg/dl)

-0.28(0.24)

0.248

-39.44(18.58)

0.035

Waist circumference (cm)

0.05(0.16)

0.734

75.98(28.48)

0.008

Triglyceride (mg/dl)

-1.15(3.23)

0.722

0.98(1.40)

0.488

SBP (mmHg)

0.12(0.25)

0.622

32.70(17.79)

0.070

DBP (mmHg)

0.13(0.16)

0.432

49.45(28.19)

0.081

Abdominal fat (%)

0.0009(0.0008)

0.261

12133.46(5445.95)

0.027

Body fat (kg)

0.05(0.10)

0.594

87.27(45.71)

0.058

Body fat (%)

0.08(0.10)

0.395

85.12(47.94)

0.078

BMI (m2/kg)

0.04(0.06)

0.482

182.58(77.65)

0.020

  1. Data are presented as estimates [standard error]. Estimate, difference in factor per year of epigenetic age acceleration. Chronological age, sex, and regional area were included in multiple linear regression. AgeAccelGrim DNAm GrimAge Acceleration, DNAmPAI1AdjAge age-adjusted DNAmPAI1, HDL high-density lipoprotein, SBP systolic blood pressure, DBP diastolic blood pressure, BMI body mass index
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Clinical Epigenetics

ISSN: 1868-7083

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