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Table 3 Odds ratios for metabolic syndrome for accelerated GrimAge and age-adjusted DNAmPAI1

From: The influences of DNA methylation and epigenetic clocks, on metabolic disease, in middle-aged Koreans

  AgeAccelGrim p value DNAmPAI1AdjAge p value
Age group     
 Middle-aged (< 60 years) 1.16 [1.1, 1.35] 0.046 1.0003[1.0001, 1.0004] < 0.001
 Elderly (≥ 60 years) 1.07 [0.94, 1.23] 0.311 1.0001 [1, 1.0002] 0.023
Living area     
 Rural 1.05 [0.93, 1.19] 0.465 1.0001 [1, 1.0002] 0.047
 Urban 1.06 [0.98, 1.15] 0.123 1.0004 [1.0002, 1.0005] < 0.001
Sex     
 Female 1.15 [1, 1.33] 0.047 1.0001 [1, 1.0003] 0.007
 Male 1.06 [0.92, 1.21] 0.446 1.0002 [1.0001, 1.0004] < 0.001
Smoking     
 Never smoker 1.2 [1.05, 1.37] 0.007 1.0002 [1.0001, 1.0003] < 0.001
 Former smoker 0.9 [0.71, 1.14] 0.384 1.0001 [0.9999, 1.0004] 0.210
 Current smoker 1.21 [0.95, 1.54] 0.123 1.0004 [1.0002, 1.0007] < 0.001
Alcohol drinking     
 Never drinker 1.19 [1.02, 1.39] 0.021 1.0001 [1, 1.0002] 0.020
 Regular drinker 1.03 [0.9, 1.19] 0.655 1.0002 [1.0001, 1.0004] < 0.001
  1. Data are presented as Odds ratio [95% confidence interval] of metabolic syndrome. AceAccelGrim, accelerated DNAm GrimAge; DNAmPAIAdjAge, age-adjusted DANmPAI1; chronological age, sex, regional area and DNAmPACKYRS were included in the multiple linear regression