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Table 2 Differences of DNA methylation age between MetS and control groups

From: The influences of DNA methylation and epigenetic clocks, on metabolic disease, in middle-aged Koreans

 

Control

MetS

p value

Age, years

59.74 (8.21)

62.25 (8.49)

< 0.001

DNAmAge (years)

   

 Pan-tissue

62.99 (7.62)

62.05 (7.53)

0.262

 Hannum

66.46 (7.60)

67.49 (7.21)

0.204

 PhenoAge

56.02 (8.30)

56.50 (7.51)

0.569

 GrimAge

65.05 (7.16)

67.21 (6.52)

0.004

SEM

2.89 (0.02)

2.88 (0.02)

0.710

DNAm-based Protein surrogates

  

 DNAm ADM

347.94 (19.71)

353.19 (22.35)

0.026

 DNAm B2M

1695400.53 (118063.24)

17164680.23 (111301.02)

0.093

 DNAm CystatinC

657922.87 (30767.76)

663421.07 (33629.34)

0.125

 DNAm GDF15

778.64 (114.38)

792.13 (110.96)

0.275

 DNAm Leptin

6425.81 (3842.37)

6812.72 (3994.74)

0.371

 DNAm PAI1

18346.47 (3169.11)

19880.95 (2926.86)

< 0.001

 DNAm TIMP1

34309.52 (1239.02)

34686.02 (1147.70)

0.004

 DNAm Packyrs

23.57 (12.70)

23.88 (12.05)

0.813

  1. Data are presented mean (standard deviation) using Student’s t test or Mann–Whitney U test. SEM, stochastic epigenetic mutation; DNAm ADM adrenomedulin, DNAm B2M beta-2-microglobulin, DNAm cystatin C cystatin C, DNAM GDF15 growth differentiation factor 15, DNAm leptin leptin, DNAm PAI1 plasminogen activation inhibitor 1, DNAm TIMP1 tissue inhibitor metalloproteinase