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Table 2 Differences of DNA methylation age between MetS and control groups

From: The influences of DNA methylation and epigenetic clocks, on metabolic disease, in middle-aged Koreans

  Control MetS p value
Age, years 59.74 (8.21) 62.25 (8.49) < 0.001
DNAmAge (years)    
 Pan-tissue 62.99 (7.62) 62.05 (7.53) 0.262
 Hannum 66.46 (7.60) 67.49 (7.21) 0.204
 PhenoAge 56.02 (8.30) 56.50 (7.51) 0.569
 GrimAge 65.05 (7.16) 67.21 (6.52) 0.004
SEM 2.89 (0.02) 2.88 (0.02) 0.710
DNAm-based Protein surrogates   
 DNAm ADM 347.94 (19.71) 353.19 (22.35) 0.026
 DNAm B2M 1695400.53 (118063.24) 17164680.23 (111301.02) 0.093
 DNAm CystatinC 657922.87 (30767.76) 663421.07 (33629.34) 0.125
 DNAm GDF15 778.64 (114.38) 792.13 (110.96) 0.275
 DNAm Leptin 6425.81 (3842.37) 6812.72 (3994.74) 0.371
 DNAm PAI1 18346.47 (3169.11) 19880.95 (2926.86) < 0.001
 DNAm TIMP1 34309.52 (1239.02) 34686.02 (1147.70) 0.004
 DNAm Packyrs 23.57 (12.70) 23.88 (12.05) 0.813
  1. Data are presented mean (standard deviation) using Student’s t test or Mann–Whitney U test. SEM, stochastic epigenetic mutation; DNAm ADM adrenomedulin, DNAm B2M beta-2-microglobulin, DNAm cystatin C cystatin C, DNAM GDF15 growth differentiation factor 15, DNAm leptin leptin, DNAm PAI1 plasminogen activation inhibitor 1, DNAm TIMP1 tissue inhibitor metalloproteinase