Skip to main content

Table 1 Anthropometric (A) and analytical (B) parameters at baseline, after 4 months, and 12 months of intervention in the total study population and by gender (mean ± SD)

From: Epigenetic approach in obesity: DNA methylation in a prepubertal population which underwent a lifestyle modification

 

Baseline (B)

4 months (4 m)

12 months (12 m)

p (B vs 4 m)

p (B vs 12 m)

A

Body weight (kg)

All

46.2 ± 10.2

46.9 ± 10.5

50.2 ± 11.1

0.6

< 0.001

Boys

48.2 ± 10.0

48.9 ± 10.5

50.7 ± 11.2

0.7

< 0.001

Girls

44.0 ± 10.0

44.8 ± 10.1

49.7 ± 11.0

0.7

< 0.001

Height (cm)

All

136.0 ± 9.2

137.9 ± 8.9

141.9 ± 9.1

0.1

< 0.001

Boys

138.4 ± 7.9

140.3 ± 7.9

143.2 ± 9.0

0.2

< 0.001

Girls

133.3 ± 9.4

135.2 ± 9.2

140.6 ± 9.1

0.3

< 0.001

BMI (kg/m2)

All

24.7 ± 3.5

24.4 ± 3.5

24.7 ± 3.9

0.6

0.1

Boys

25.0 ± 3.7

24.6 ± 3.7

24.6 ± 4.3

0.6

0.6

Girls

24.3 ± 3.2

24.2 ± 3.2

24.8 ± 3.6

0.8

0.04

WC (cm)

All

79.8 ± 9.0

80.6 ± 9.7

81.2 ± 9.7

0.5

0.001

Boys

81.4 ± 9.9

82.4 ± 10.3

82.4 ± 10.5

0.6

0.003

Girls

78.1 ± 7.7

78.8 ± 8.6

79.9 ± 8.7

0.7

0.1

SBP/DBP (mmHg)

All

107 ± 12/69 ± 11

108 ± 13/70 ± 9

110 ± 12/71 ± 10

0.7/0.3

0.02/0.3

Boys

108 ± 11/71 ± 11

109 ± 10/70 ± 7

109 ± 10/70 ± 8

0.5/0.7

0.5/0.6

Girls

105 ± 14/67 ± 10

106 ± 16/71 ± 11

111 ± 13/71 ± 12

0.8/0.1

0.001/0.1

B

Glucose (mg/dL)

NV 70–110

All

81.1 ± 9.1

80.5 ± 9.8

85.4 ± 7.7

0.64

< 0.001

Boys

81.8 ± 7.7

81,3 ± 10.0

84.8 ± 7.4

0.78

0.03

Girls

80.2 ± 10.5

79.5 ± 9.6

86.1 ± 8.2

0.71

< 0.001

HbA1c (%)

NV 4.0–6.0

All

5.29 ± 0.24

5.29 ± 0.23

5.26 ± 0.24

0.55

< 0.001

Boys

5.29 ± 0.23

5.27 ± 0.24

5.25 ± 0.23

0.75

0.001

Girls

5.30 ± 0.24

5.30 ± 0.23

5.28 ± 0.26

0.87

0.05

Insulin (μUI/mL)

NV 4.0–16.0

All

21.2 ± 11.5

19.1 ± 10.9

14.6 ± 7.7

0.16

< 0.001

Boys

20.6 ± 9.7

18.0 ± 8.0

14.0 ± 6.7

0.13

< 0.001

Girls

22.0 ± 13.2

20.5 ± 12.8

15.3 ± 8.9

0.57

< 0.001

HOMA-IR index

NV ≤ 3.4

All

4.3 ± 2.4

3.9 ± 2.6

3.1 ± 1.8

0.19

< 0.001

Boys

4.2 ± 2.0

3.7 ± 2.1

2.9 ± 1.5

0.18

< 0.001

Girls

4.5 ± 2.8

4.1 ± 3.0

3.3 ± 2.1

0.55

0.001

Total cholesterol (mg/dL)

NV < 200 mg/dL

All

162.1 ± 27.3

161.9 ± 30.0

160.7 ± 26.5

0.9

0.71

Boys

162.5 ± 29.4

164.8 ± 31.1

160.4 ± 26.6

0.67

0.80

Girls

161.6 ± 25.0

158.8 ± 28.8

161.0 ± 26.7

0.57

0.33

LDL-c (mg/dL)

NV < 130 mg/dL

All

95.2 ± 22.5

95.6 ± 23.4

96.1 ± 23.7

0.93

0.41

Boys

95.5 ± 24.6

96.9 ± 23.7

96.1 ± 24.9

0.77

0.86

Girls

95 ± 20.0

93.7 ± 23.2

96.1 ± 22.6

0.79

0.28

HDL-c (mg/dL)

NV > 50 mg/dL

All

49.4 ± 11.3

45.9 ± 11.6

48.0 ± 10.7

0.04

0.39

Boys

49.9 ± 11.4

48.3 ± 11.9

48.5 ± 10.9

0.50

0.51

Girls

48.7 ± 11.2

42.5 ± 10.5

47.3 ± 10.6

0.01

0.59

TG (mg/dL)

NV < 150 mg/dl

All

77.0 (59.0–100.0)

58 (76–99.8)

73 (55–103)

0.75

0.49

Boys

77.0 (58–100.0)

71 (51–193.8)

72 (52–99)

0.44

0.66

Girls

77.0 (62.8–99.3)

82.2 (61.0–106.3)

76 (56–107)

0.23

0.60

IL-6 (pg/ml)

NV 3.13–12.5

All

0.18 ± 0.16

0.19 ± 0.15

0.98 ± 1.19

0.06

< 0.001

Boys

0.17 ± 0.16

0.18 ± 0.16

0.88 ± 1.08

0.13

0.001

Girls

0.20 ± 0.16

0.20 ± 0.15

1.08 ± 1.31

0.30

< 0.001

TNFa (pg/ml)

NV < 15.6

All

0.21 ± 0.16

0.19 ± 0.15

0.35 ± 0.38

0.03

< 0.001

Boys

0.21 ± 0.15

0.18 ± 0.14

0.32 ± 0.34

0.01

< 0.001

Girls

0.22 ± 0.18

0.19 ± 0.17

0.38 ± 0.43

0.55

< 0.001

  1. (A) BMI body mass index, WC waist circumference, SBP systolic blood pressure, DBP diastolic blood pressure
  2. All, n = 131 participants (n = 70 boys and n = 61 girls; p = 0.65)
  3. (B) HbA1c glycosylated hemoglobin A1c, HOMA-IR Homeostatic Model Assessment of Insulin Resistance, LDL-c low-density lipoprotein cholesterol, HDL-c high-density lipoprotein cholesterol, TG triglycerides, IL-6 interleukin 6, TNFa tumor necrosis factor alpha
  4. All, n = 131 participants (n = 70 boys and n = 61 girls; p = 0.65)
Back to article page

Clinical Epigenetics

ISSN: 1868-7083

Contact us