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Table 2 Association between cocaine use frequency and HIV severity and survival analysis among HIV-positive participants (n = 1435)

From: DNA methylation mediates the effect of cocaine use on HIV severity

 

HIV severitya

Mortalityb

 

Estimate

SE

T

p value

Hazard ratio

95% CI

Z

p value

Cocaine use frequencyc

1.00

0.28

3.65

2.70E−04

1.10

(1.02, 1.19)

2.54

1.10E−02

Sex (reference: male)

5.78

2.33

2.48

1.34E−02

0.27

(0.07, 1.08)

− 1.86

6.33E−02

Agec

1.09

0.05

23.58

< 2E−16

1.05

(1.04, 1.07)

7.35

1.90E−13

Race (reference: Caucasian)

        

 African American

7.30

0.94

7.73

2.00E−14

1.05

(0.80, 1.39)

0.37

7.15E−01

 Others

5.33

1.31

4.08

4.80E−05

0.71

(0.47, 1.09)

− 1.57

1.17E−01

log 10 viral loadc

4.72

0.36

13.11

< 2eE−16

1.07

2

1.36

1.73E−01

CD4 countc

− 0.03

0.00

− 19.05

< 2E−16

1.00

(1.00, 1.00)

− 3.74

1.80E−04

Antiviral medication adherencec

2.59

0.99

2.62

8.87E−03

1.02

(0.76, 1.37)

0.13

8.95E−01

  1. aSummary statistics from the linear regression model
  2. bSummary statistics from the Cox proportional hazards model
  3. cMeasured at baseline