Fig. 3

Association between differential DNA methylation and gene expression. a Plot of 53,617 probes used in the analysis. Red/Blue = Bonferroni adjusted p value < 0.05. Airway fibroblasts were used as reference. The horizontal dotted line indicates the p value corresponded to Bonferroni adjusted p value 0.05. Red = greater expression in parenchymal fibroblasts, blue = greater expression in airway fibroblasts. b Change in DNA methylation plotted against change in gene expression. c Gene feature type for all differentially methylated probes associated with a gene that is differentially expressed, differentially methylated probes and differentially expressed genes that display a direct relationship and differentially methylated probes and differentially expressed genes that display an inverse relationship. d CpG Density for all differentially methylated probes associated with a gene that is differentially expressed, differentially methylated probes and differentially expressed genes that display a direct relationship and differentially methylated probes and differentially expressed genes that display an inverse relationship