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Fig. 10 | Clinical Epigenetics

Fig. 10

From: TWIST1 DNA methylation is a cell marker of airway and parenchymal lung fibroblasts that are differentially methylated in asthma

Fig. 10

Validation of differential methylation between airway and parenchymal fibroblasts and associated gene expression. a Plot of 240 CpG probes used in the analysis. Red/Blue = Bonferroni adjusted p value < 0.05. Red = greater expression in parenchymal fibroblasts, blue = greater expression in airway fibroblasts. b Summary of regional DNA methylation differences within the 240 CpG probes used in the analysis, between DNA isolated from airway versus parenchymal fibroblasts. c Regional beta value plots for TWIST1 in paired samples. d Regional beta value plot for HLX in paired samples. e Regional beta value plot for SKAP2 in paired samples. Microarray generated gene expression in paired airway and parenchymal fibroblasts for f TWIST1, g HLX and h SKAP2 (**limma moderated t test p < 0.01)

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Clinical Epigenetics

ISSN: 1868-7083

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