Fig. 5

The yellow methylation group is characterized by differential methylation of genes involved in genomic structure and translation. a The Venn diagram shows the distribution of DMPs between the three differentially methylated groups. The top left circle represents DMPs between the blue and yellow groups. The top right circle represents DMPs between blue and pink groups. The bottom circle represents DMPs between the pink and yellow groups. b The heatmap shows the hierarchical clustering of participants using the 237 DMPs that were observed between yellow vs blue and yellow vs pink, but not blue vs pink. DMPs were associated with genomic features including (c) CpG islands and (d) coding genes. Gene ontology enrichment analysis was performed on E) all DMPs and F) only hypermethylated DMPs. All reported DMPs have FDR p-value >0.01