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Fig. 7 | Clinical Epigenetics

Fig. 7

From: IFN-α confers epigenetic regulation of HBV cccDNA minichromosome by modulating GCN5-mediated succinylation of histone H3K79 to clear HBV cccDNA

Fig. 7

A model of histone H3K79 succinylation modulating the epigenetic regulation of HBV cccDNA minichromosome. In this model, histone H3K79 succinylation is identified, which contributes to the epigenetic regulation of the HBV cccDNA minichromosome, leading to HBV replication. GCN5 is responsible for histone H3K79 succinylation of the HBV cccDNA minichromosome. IFN-α is able to inhibit histone H3K79 succinylation of HBV cccDNA minichromosome

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Clinical Epigenetics

ISSN: 1868-7083

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