Association between NPPA promoter methylation and hypertension: results from Gusu cohort and replication in an independent sample

Table 2 The levels of NPPA promoter methylation in participants with and without hypertension

CpG loci	Genomic position, GRCh37	Relative to TSS, bp	Discovery sample				Replication sample
CpG loci	Genomic position, GRCh37	Relative to TSS, bp	non-HBP	HBP	P	q	non-HBP	HBP	P	q
CpG1	Chr1:11908353	− 513	29.02 ± 5.13	27.96 ± 5.28	< 0.001	< 0.001	28.95 ± 5.24	27.17 ± 5.05	< 0.001	< 0.001
CpG2	Chr1:11908348	− 508	93.27 ± 2.46	93.03 ± 2.59	0.019	0.025	93.02 ± 2.40	92.92 ± 2.72	0.420	0.420
CpG3	Chr1:11908299	− 459	22.99 ± 3.84	22.64 ± 3.83	0.024	0.027	22.91 ± 4.20	22.45 ± 3.76	0.016	0.049
CpG4	Chr1:11908200	− 360	68.59 ± 6.36	67.90 ± 6.62	0.008	0.013	68.23 ± 6.74	67.67 ± 6.85	0.086	0.154
CpG5	Chr1:11908182	− 342	81.96 ± 4.81	81.32 ± 4.98	0.001	0.002	81.53 ± 4.93	81.14 ± 5.28	0.011	0.163
CpG6	Chr1:11908178	− 338	40.43 ± 6.05	39.60 ± 6.18	< 0.001	0.002	40.35 ± 6.18	39.12 ± 6.20	< 0.001	< 0.001
CpG7	Chr1:11908168	− 328	50.67 ± 6.34	49.81 ± 6.54	< 0.001	0.002	50.14 ± 6.39	49.71 ± 6.77	0.017	0.219
CpG8	Chr1:11908165	− 325	31.13 ± 6.33	30.11 ± 6.48	< 0.001	< 0.001	30.48 ± 6.41	29.82 ± 6.56	0.033	0.075
CpG9	Chr1:11908142	− 302	36.84 ± 7.63	36.15 ± 7.87	0.027	0.027	36.21 ± 7.75	36.63 ± 7.91	0.026	0.291
Average			50.55 ± 4.69	49.84 ± 4.88	< 0.001	-	50.20 ± 4.78	49.62 ± 5.06	0.014	-

P values indicate the significance level of the differences between two groups calculated by t test. q values indicate the significance level after correction of multiple testing by false discovery rate approach. The values in bold indicate a statistical significance level at < 0.05

ISSN: 1868-7083