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Table 1 Maternal and birth characteristics of the study population

From: Associations of maternal early-pregnancy blood glucose and insulin concentrations with DNA methylation in newborns

Characteristics

Total group, n = 935

Maternal normal weight, n = 667

Maternal overweight/obesity, n = 234

p value

Maternal characteristics

 Age, years

31.7 ± 4.2

31.8 ± 4.2

31.7 ± 4.1

0.69

 Height, cm

170.8 ± 6.2

171.1 ± 6.3

170.4 ± 5.8

0.25

 Pre-pregnancy body mass index, kg/m2

23.3 ± 3.8

21.8 ± 1.6

28.5 ± 3.4

< 0.01

 Women with

  Underweight

34 (3.6)

–

–

 

  Normal weight

667 (71.3)

667

–

 

  Overweight

175 (18.7)

–

175

 

  Obesity

59 (6.3)

–

59

 

 Gestational age at glucose/insulin measurement, weeks

13.1 (9.4–17.4)

13.4 (8.3–17.4)

12.9 (9.5–17.5)

0.19

 Parity, nulliparous

563 (60.3)

409 (61.3)

130 (55.6)

0.23

 Education, higher education

596 (64.9)

405 (71.6)

97 (50.0)

< 0.01

 Smoking during pregnancy, continued

173 (20.8)

101 (19.6)

40 (22.6)

0.40

 Glucose, mmol/l

4.4 ± 0.8

4.4 ± 0.8

4.5 ± 0.8

0.08

 Insulin, pmol/l

126.3 (19.9–774.6)

119.6 (19.6–764.5)

153.6 (19.0–847.4)

0.09

 Gestational diabetes

10 (1.3)

8 (1.7)

1 (0.5)

0.31

Child characteristics

 Male

491 (52.5)

311 (54.4)

96 (49.0)

0.19

 Gestational age at birth, weeks

40.3 (36.4–42.3)

40.4 (36.5–42.3)

40.4 (36.3–42.3)

0.60

 Birth weight, grams

3552 ± 514

3552 ± 493

3599 ± 571

0.31

 Glucose, mmol/l

5.2 (0.9)

5.2 (0.9)

5.0 (0.9)

0.03

  1. Values are means ± SD, medians (95% range) or numbers of subjects (valid %) shown for the total group and stratified for maternal pre-pregnancy body mass index. The stratified groups are normal weight versus overweight or obese women (data for underweight women are not separately shown n = 34). Differences were tested using Student’s t tests and Mann-Whitney tests for normally and non-normally distributed variables, respectively, and χ2 test were used for dichotomous variables