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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Universal NicE-seq for high-resolution accessible chromatin profiling for formaldehyde-fixed and FFPE tissues

Fig. 5

One tube UniNicE-seq of 5–10-μm human liver FFPE tissue sections. a Workflow diagram of one tube universal NicE-seq. (b) Venn diagram demonstrating common accessible regions in two different human 5–10-μm liver normal FFPE tissue sections designated as R1 and R2. c Peak annotation of accessible peaks of liver FFPE tissue section showing the genomic feature distribution. d Heatmap and signal intensity profile plot of TSS (that includes ±2 Kb of flanking region) in liver FFPE tissue section. e Heatmap and signal intensity profile plot of active enhancer elements (that includes ±2 Kb of flanking region) in liver FFPE tissue section. f Representative IGV screen shot of accessible chromatin peaks of two liver FFPE tissue section and histone marks, H3K27Ac, H3K4me3, and H3K4me1

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Clinical Epigenetics

ISSN: 1868-7083

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