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Table 6 Disease association of DMC genes identified according to severe features (GRCh37/hg19 assembly)

From: Epigenome-wide DNA methylation profiling of preeclamptic placenta according to severe features

Disease Gene symbol rawP adjP
Disease susceptibility MSX1, RBFOX1, GABBR1, CNTNAP2, TCERG1L, HLA-DPB1, HLA-DRB1, SORCS1, GABRB3, ADGRB3, CHRNB3, CSMD1, MAGI2, ZFAT, FAM69A, CHRNB4, PSORS1C1 3.69e−07 7.63e−05
Viral infections KLK5, WNT2, TNFRSF10B, ITGA5, CD80, LOXL2, WISP2, FGFR3, CBFA2T3, WWOX, PAX8, KRT19, IKZF1, IGF2 0.0002 0.0016
Immune system diseases HLA-F, CD80, HLA-DPB1, HLA-DPA1, HLA-DRB1, ATIC, HLA-DQB2, PTPRN2, RNF39, IKZF1, INS-IGF2 0.0004 0.0023
Endocrine disturbance NOS KLK5, BCL11A, HLA-DRB1, WWOX, PAX8, PTPRN2, KRT19, INS-IGF2, IGF2 0.0002 0.0016
Seizures DNAJC5, GABBR1, CACNA1A, CNTNAP2, GABRB3, HCN1 0.0006 0.0031
Hematologic diseases PRDM16, SPTB, BCL11A, HLA-DRB1, FGFR3, IKZF1 0.0037 0.0086
Thyroid diseases HLA-DRB1, PAX8, KRT19, INS-IGF2, ZFAT 0.0003 0.0020
  1. rawP P value from hypergeometric test, adjP P value adjusted by the multiple test adjustment