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Table 5 GO analysis of DMC genes identified according to severe features (GRCh37/hg19 assembly)

From: Epigenome-wide DNA methylation profiling of preeclamptic placenta according to severe features

  Pathway Gene symbol rawP adjP
BP System development TRIM10, ADAM19, ROBO2, GAS7, HLA-F, WNT2, RXRA, OTX1, SLIT3, PBX1, NRN1, CREB5, CNTNAP2, PPP1R17, HLA-DPB1, SPTB, CTNNA2, HLA-DRB1, HLA-DPA1, FGFR3, PLXNA4, GPRIN1, STK3, CBFA2T3, ATIC, CDH13, KRT19, ITGA1, LSAMP, KIRREL3, ZFAT, MSX1, KLK5, PRDM16, OSTM1, CACNA1A, ITGA5, CD80, LOXL2, ZIC1, BCL11A, PCDHB11, UBD, BAI3, PAX8, WWOX, HLA-DQB2, VCAN, CPLX2, KRT2, DAB1, NFASC, SPP2, IKZF1, SHOX2, HCN1, MAGI2, IGF2, NUMB, HOXA13 2.16e−06 0.0016
  Anatomical structure development TRIM10, ADAM19, SGCZ, RXRA, OTX1, SLIT3, PBX1, NRN1, SPTB, CTNNA2, HLA-DPA1, GPRIN1, CDH13, KRT19, OSTM1, LOXL2, BCL11A, PCDH8, UBD, HLA-DQB2, CPLX2, NFASC, IKZF1, HCN1, MAGI2, NUMB, HOXA13, BIN1, SPAG16, GAS7, ROBO2, HLA-F, WNT2, CNTNAP2, CREB5, PPP1R17, HLA-DPB1, HLA-DRB1, PLXNA4, FGFR3, STK3, CBFA2T3, ATIC, LSAMP, ITGA1, KIRREL3, ZFAT, KLK5, MSX1, PRDM16, CACNA1A, ITGA5, CD80, ZIC1, PCDHB11, BAI3, WWOX, PAX8, VCAN, KRT2, DAB1, SPP2, SHOX2, IGF2 9.46e−06 0.0018
  Developmental process TRIM10, ADAM19, SGCZ, RXRA, OTX1, SLIT3, PBX1, NRN1, SPTB, CTNNA2, HLA-DPA1, GPRIN1, CDH13, KRT19, OSTM1, LOXL2, EBF3, BCL11A, PCDH8, UBD, HLA-DQB2, CPLX2, NFASC, IKZF1, HCN1, MAGI2, NUMB, HOXA13, BANP, BIN1, SPAG16, GAS7, ROBO2, JDP2, HLA-F, GABBR1, WNT2, CNTNAP2, CREB5, PPP1R17, HLA-DPB1, HLA-DRB1, PLXNA4, FGFR3, STK3, CBFA2T3, ATIC, MAPK9, LSAMP, ITGA1, KIRREL3, ZFAT, KLK5, MSX1, PRDM16, CACNA1A, ITGA5, CD80, ZIC1, PCDHB11, BAI3, PAX8, WWOX, VCAN, KRT2, DAB1, SPP2, SPRED3, SHOX2, IGF2 9.35e−06 0.0018
  Nervous system development ROBO2, GAS7, WNT2, RXRA, OTX1, SLIT3, PBX1, NRN1, CNTNAP2, PPP1R17, SPTB, CTNNA2, FGFR3, PLXNA4, STK3, GPRIN1, ITGA1, LSAMP, KIRREL3, MSX1, PRDM16, CACNA1A, ITGA5, BCL11A, ZIC1, PCDHB11, PAX8, VCAN, CPLX2, DAB1, NFASC, IKZF1, SHOX2, HCN1, NUMB 2.01e−05 0.0018
  Organ development TRIM10, ADAM19, ROBO2, HLA-F, WNT2, RXRA, OTX1, SLIT3, PBX1, CREB5, CNTNAP2, HLA-DPB1, SPTB, CTNNA2, HLA, DRB1, HLA-DPA1, FGFR3, PLXNA4, STK3, CBFA2T3, ATIC, KRT19, KIRREL3, ZFAT, MSX1, KLK5, PRDM16, OSTM1, CACNA1A, CD80, LOXL2, ZIC1, BCL11A, UBD, PAX8, WWOX, VCAN, HLA-DQB2, KRT2, DAB1, IKZF1, SHOX2, MAGI2, HCN1, NUMB, HOXA13 1.53e−05 0.0018
  Single-multicellular organism process TRIM10, ADAM19, OR8G1, RXRA, OTX1, SLIT3, PBX1, NRN1, SPTB, CTNNA2, HLA-DPA1, GPRIN1, RIMS1, P2RX6, CDH13, KRT19, OSTM1, LOXL2, TANC1, EBF3, BCL11A, GABRB3, PCDH8, UBD, HLA-DQB2, CPLX2, NFASC, IKZF1, HCN1, MAGI2, NUMB, HOXA13, BANP, BIN1, DNAJC5, SPAG16, GAS7, ROBO2, HLA-F, GABBR1, WNT2, CNTNAP2, CREB5, PPP1R17, HLA-DPB1, HLA-DRB1, PLXNA4, FGFR3, STK3, CBFA2T3, CHRNB3, ATIC, LSAMP, ITGA1, KIRREL3, ZFAT, KCNJ16, MSX1, KCNA6, KLK5, CACNA1E, PRDM16, CACNA1A, PRKAR1B, ITGA5, CD80, ZIC1, DLGAP2, PCDHB11, BAI3, PAX8, WWOX, VCAN, KRT2, DAB1, SPP2, SPRED3, SHOX2, IGF2, CHRNB4 1.96e−05 0.0018
  Cell morphogenesis involved in differentiation MSX1, ROBO2, CACNA1A, WNT2, RXRA, ITGA5, SLIT3, LOXL2, SPTB, CTNNA2, BCL11A, PLXNA4, FGFR3, PAX8, VCAN, DAB1, NFASC, ITGA1, NUMB, HOXA13 1.85e−05 0.0018
  Multicellular organismal development TRIM10, ADAM19, RXRA, OTX1, SLIT3, PBX1, NRN1, SPTB, CTNNA2, HLA-DPA1, GPRIN1, CDH13, KRT19, OSTM1, LOXL2, EBF3, BCL11A, PCDH8, UBD, HLA-DQB2, CPLX2, NFASC, IKZF1, HCN1, MAGI2, NUMB, HOXA13, BANP, BIN1, GAS7, ROBO2, HLA-F, WNT2, CNTNAP2, CREB5, PPP1R17, HLA-DPB1, HLA-DRB1, PLXNA4, FGFR3, STK3, CBFA2T3, ATIC, LSAMP, ITGA1, KIRREL3, ZFAT, KLK5, MSX1, PRDM16, CACNA1A, ITGA5, CD80, ZIC1, PCDHB11, BAI3, WWOX, PAX8, VCAN, KRT2, DAB1, SPP2, SPRED3, SHOX2, IGF2 6.54e−06 0.0018
  Cell differentiation BIN1, TRIM10, ROBO2, GAS7, SGCZ, JDP2, WNT2, GABBR1, RXRA, SLIT3, PBX1, CREB5, CNTNAP2, SPTB, CTNNA2, FGFR3, PLXNA4, GPRIN1, STK3, CBFA2T3, MAPK9, KRT19, ITGA1, KIRREL3, ZFAT, MSX1, PRDM16, OSTM1, CACNA1A, ITGA5, CD80, LOXL2, ZIC1, BCL11A, UBD, PAX8, WWOX, VCAN, CPLX2, KRT2, DAB1, NFASC, IKZF1, MAGI2, HCN1, HOXA13, NUMB 2.12e−05 0.0018
MF Cadherin binding CDH13, PTPRT, CTNNA2, NUMB, HLA-DRB1, HLA-DPA1, HLA-DQB2 8.88e−05 0.0114
CC Synapse part BIN1, DLGAP2, GABRB3, DNAJC5, PCDH8, RIMS1, CHRNB3, P2RX6, GABBR1, SYT3, PTPRN2, TANC1, MAGI2, CHRNB4 1.13e−05 0.0004
  Axon BIN1, DLGAP2, ROBO2, GABBR1, RXRA, PTPRN2, NFASC, CNTNAP2, TANC1, HCN1, KIRREL3, CTNNA2 1.78e−05 0.0004
  MHC class II protein complex HLA-DRB1, HLA-DPA1, HLA-DPB1, HLA-DQB2 1.28e−05 0.0004
  ER to Golgi transport vesicle HLA-DRB1, HLA-DPA1, HLA-DPB1, HLA-DQB2, HLA-F 4.01e−05 0.0006
  Clathrin-coated vesicle HLA-DRB1, BIN1, HLA-DPA1, DNAJC5, HLA-DQB2, GABBR1, SYT3, SH3BP4, HLA-DPB1 0.0002 0.0018
  Cell projection BIN1, SPAG16, ROBO2, GAS7, CACNA1A, GABBR1, RXRA, ITGA5, CNTNAP2, TANC1, CTNNA2, DLGAP2, PCDH8, GPRIN1, WWOX, P2RX6, CDH13, CPLX2, PTPRN2, NFASC, ITGA1, HCN1, KIRREL3, MAGI2 0.0005 0.0038
  Plasma membrane DNAJC5, ROBO2, HCAR1, OR8G1, SGCZ, OR10R2, HLA-F, WNT2, GABBR1, CD1C, NRN1, CNTNAP2, HLA-DPB1, SPTB, CTNNA2, WISP2, HLA-DRB1, HLA-DPA1, FGFR3, PLXNA4, GPRIN1, RIMS1, TEX101, CHRNB3, P2RX6, CDH13, PTPRT, HCAR3, KRT19, ITGA1, LSAMP, KIRREL3, KCNJ16, KCNA6, CACNA1E, TICAM2, TNFRSF10B, CACNA1A, ITGA5, CD80, TANC1, OR10J5, DLGAP2, RIMBP2, PCDHB11, GABRB3, PCDH8, BAI3, WWOX, HLA-DQB2, PTPRN2, NFASC, HCN1, MAGI2, NUMB, CHRNB4 0.0039 0.0170
  Cell periphery DNAJC5, ROBO2, HCAR1, OR8G1, SGCZ, OR10R2, HLA-F, WNT2, GABBR1, CD1C, NRN1, CNTNAP2, HLA-DPB1, SPTB, CTNNA2, WISP2, HLA-DRB1, HLA-DPA1, FGFR3, PLXNA4, GPRIN1, RIMS1, TEX101, CHRNB3, P2RX6, CDH13, PTPRT, HCAR3, KRT19, ITGA1, LSAMP, KIRREL3, KCNJ16, KCNA6, CACNA1E, TICAM2, TNFRSF10B, CACNA1A, ITGA5, CD80, TANC1, OR10J5, DLGAP2, RIMBP2, PCDHB11, GABRB3, PCDH8, BAI3, WWOX, HLA-DQB2, PTPRN2, NFASC, HCN1, MAGI2, NUMB, CHRNB4 0.0062 0.0235
  1. BP Biological process, MF Molecular function, CC Cellular component, rawP P value from hypergeometric test, adjP P value adjusted by the multiple test adjustment