Epigenome-wide DNA methylation profiling of preeclamptic placenta according to severe features

Clinical Epigenetics

Table 4 DNA methylation around PE-related SNPs (GRCh37/hg19 assembly)

Probe ID	MAPINFO	SNP_ID	Control (n = 13)	PE (n = 5)	PE with severe feature (n = 8)	P	Bonferroni
Probe ID	MAPINFO	SNP_ID	Control (n = 13)	PE (n = 5)	PE with severe feature (n = 8)	P	P^a	P^b	P^c
cg11348599	29,073,223	rs192147271 rs74619608 rs550918608	0.59	0.51	0.53	0.030	0.037	0.358	1.000
cg15188434*	29,105,629	rs192139036	0.69	0.67	0.70	0.794	1.000	1.000	1.000
cg08962087	29,107,120	rs569310504 rs537887549 rs75417109	0.19	0.10	0.15	0.004	0.002	0.362	0.002
cg07027493^#	29,138,219	rs7320190 rs560703568	0.47	0.48	0.47	0.975	1.000	1.000	1.000
cg10329331^#	29,139,026	rs545690604 rs18598099 rs113006545	0.97	0.97	0.97	0.831	1.000	1.000	1.000
cg15887927	29,148,952	rs540334005 rs377281528 rs528914368	0.53	0.41	0.50	0.003	0.001	0.001	0.063
cg19371105	29,159,914	rs550630513 rs369261321	0.92	0.84	0.92	0.015	0.002	1.000	0.020
cg18469224	29,160,247	rs537961884	0.95	0.96	0.96	0.044	0.242	0.072	1.000
cg16463452	29,195,249	rs138779088	0.88	0.81	0.89	0.028	0.001	1.000	0.004
cg08931404^†	29,227,083	rs563719373 rs532541556	0.87	0.88	0.90	0.224	1.000	0.272	0.553

Continuous variables are presented as mean
Kruskal-Wallis test, followed by the Bonferroni correlation for multiple testing
P^a control versus PE, P^b control versus PE with severe features, P^c PE versus PE with severe features
PE-related SNPs: *rs149427560 (MAPINFO: 29,105,870); ^#rs4769613 (MAPINFO: 29,138,609); ^†rs12050029 (MAPINFO: 29,227,519)

ISSN: 1868-7083