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Table 2 Distribution of DMCs on functional genomic regions

From: Epigenome-wide DNA methylation profiling of preeclamptic placenta according to severe features

Functional genomic regions Control versus PE Control versus PE with severe features PE versus PE with severe features
Hypo DMCs Hyper DMCs Hypo DMCs Hyper DMCs Hypo DMCs Hyper DMCs
n % n % n % n % n % n %
1stExon 3 3.8 0 0.0 1 2.0 1 1.8 5 3.3 8 8.4
3′UTR 2 2.5 3 4.0 0 0.0 3 5.3 8 5.2 0 0.0
5′UTR 10 12.5 7 9.3 9 18.0 9 15.8 27 17.6 13 13.7
Body 51 63.8 43 57.3 28 56.0 30 52.6 96 62.7 47 49.5
TSS1500 11 13.8 16 21.3 11 22.0 13 22.8 13 8.5 15 15.8
TSS200 3 3.8 5 6.7 1 2.0 1 1.8 4 2.6 10 10.5
ExonBnd 0 0.0 1 1.3 0 0.0 0 0.0 0 0.0 2 2.1
  1. PE Preeclampsia, DMCs Differentially methylated CpGs UTR Untranslated regions, TSS Transcriptional start site, TSS200 0~200 bases upstream of TSS, TSS1500 200~1500 bases upstream of the TSS, Body between the ATG and stop codon, irrespective of the presence of introns, exons, TSS, or promoters, ExonBnd within 20 bases of an exon boundary, i.e., the start or end of an exon