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Table 2 Distribution of DMCs on functional genomic regions

From: Epigenome-wide DNA methylation profiling of preeclamptic placenta according to severe features

Functional genomic regions

Control versus PE

Control versus PE with severe features

PE versus PE with severe features

Hypo DMCs

Hyper DMCs

Hypo DMCs

Hyper DMCs

Hypo DMCs

Hyper DMCs

n

%

n

%

n

%

n

%

n

%

n

%

1stExon

3

3.8

0

0.0

1

2.0

1

1.8

5

3.3

8

8.4

3′UTR

2

2.5

3

4.0

0

0.0

3

5.3

8

5.2

0

0.0

5′UTR

10

12.5

7

9.3

9

18.0

9

15.8

27

17.6

13

13.7

Body

51

63.8

43

57.3

28

56.0

30

52.6

96

62.7

47

49.5

TSS1500

11

13.8

16

21.3

11

22.0

13

22.8

13

8.5

15

15.8

TSS200

3

3.8

5

6.7

1

2.0

1

1.8

4

2.6

10

10.5

ExonBnd

0

0.0

1

1.3

0

0.0

0

0.0

0

0.0

2

2.1

  1. PE Preeclampsia, DMCs Differentially methylated CpGs UTR Untranslated regions, TSS Transcriptional start site, TSS200 0~200 bases upstream of TSS, TSS1500 200~1500 bases upstream of the TSS, Body between the ATG and stop codon, irrespective of the presence of introns, exons, TSS, or promoters, ExonBnd within 20 bases of an exon boundary, i.e., the start or end of an exon