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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Epigenome-wide DNA methylation profiling of preeclamptic placenta according to severe features

Fig. 5

Interaction networks of DMCs according to severe features of PE. The list of the genes identified was subjected to STRING (v. 11.0) analysis to reveal functional interactions. Each node represents a protein, and each edge represents an interaction. Thicker lines represent stronger associations. Red letters and blue letters present hypermethylated and hypomethylated genes, respectively, in PE, compared to PE with severe features. Purple and orange circles represent genes that are related to disease susceptibility and IFN╬│-mediated signaling pathway, respectively. Red circles represent TICAM2 and ZNF417 containing DMCs specific to severe features of PE

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