Fig. 2

Hierarchical clustering of differentially methylated CpG sites (DMCs) according to severe features of PE. The degree values of methylation from the 850K array were assessed with an independent t test (P < 0.05) and a fold-change criterion (|delta_average of methyl degree| ≥ 0.2). The P values were corrected using the Benjamini and Hochberg false discovery rate method to control false positive results from multiple testing. The degree values of methylation for these DMCs were subjected to hierarchical clustering. Biological samples are on the x-axis and DMCs are on the y-axis with strong methylation indicated in yellow and weak or absent methylation in blue. PE, preeclampsia, PES, preeclampsia with severe features