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Table 1 Characteristics of the study population, by steatosis grade

From: Circulating histone signature of human lean metabolic-associated fatty liver disease (MAFLD)

Variable All patients (53) S1 (21) S2 (24) S3 (8) p value *
Male Sex, n (%) 44 (83.0) 20 (95.2) 17 (70.8) 7 (87.5) 0.08
Age, median (IQ range) 51 (43–55) 49 (40–54) 49 (43–57) 52 (44–54) 0.7
BMI, median (IQ range) 26.8 (24.6–28.7) 27.1 (24.9–28.7) 26.1 (24.6–28.7) 26.2 (23.8–29.0) 0.9
Diabetes, n (%) 7 (13.2) 2 (9.5) 5 (20.8) 0 (0) 0.2
Dyslipidemia, n (%) 27 (50.9) 10 (47.6) 14 (58.3) 3 (37.5) 0.5
Hypertension, n (%) 14 (26.4) 3 (14.3) 9 (37.5) 2 (25.0) 0.2
Platelets (×109/ml), median (IQ range) 223 (190–270) 228 (161–261) 222 (186–282) 217 (204–286) 0.5
Albumin (g/l), median (IQ range) 46 (44–48) 46 (44–48) 48 (46–50) 45 (44–47) 0.2
AST (IU/l), median (IQ range) 34 (28–51) 29 (25–50) 32 (27–56) 38 (34–51) 0.4
ALT (IU/l), median (IQ range) 60 (50–83) 54 (44–60) 69 (51–89) 80 (60–114) 0.07
g-GT (IU/l), median (IQ range) 51 (32–99) 72 (39–124) 50.5 (33–81) 30 (26–63) 0.06
Alkaline phosphatase (IU/l), median (IQ range) 118 (70–189) 90 (81–181) 113 (65–187) 182 (113–199) 0.5
Glycemia (mg/dl), median (IQ range) 88 (84–96) 85 (81–94) 89.5 (85–98) 88.5 (85–91) 0.3
Fasted insulin (mUI/l), median (IQ range) 12.6 (10.1–16.2) 10.6 (8.1–16.2) 12.2 (10.8–15.0) 14 (12.6–27.4) 0.1
HOMA-IR, median (IQ range) 2.68 (2.18–3.73) 2.4 (2.0–3.5) 2.7 (2.25–3.70) 3.14 (2.64–6.15) 0.1
Total cholesterol, median (IQ range) 203 (178–229) 207 (180–229) 203 (187–245) 179 (170–208) 0.3
HDL (mg/dl), median (IQ range) 45 (40–51) 48 (39–55) 45 (42–49) 46 (43–51) 0.7
LDL (mg/dl), median (IQ range) 136 (107–152) 136 (107–156) 143 (129–151) 101 (86–106) 0.09
Triglycerides (mg/dl), median (IQ range) 126 (85–175) 110 (77–147) 154 (97–197) 135 (108–167) 0.1
  1. p value for trend (Kruskal-Wallis test or chi2)