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Fig. 4 | Clinical Epigenetics

Fig. 4

From: The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease

Fig. 4

AD-specific methylation patterns in the newly identified AD-specific gene expression signatures. a Schematic diagram of the analysis workflow to identify AD-specific methylome patterns and AD-methylome signatures. b, c Boxplots show expression fold-changes in methylation-gain or loss on gene bodies of PPI-enriched key AD-associated genes (b), and 5mC/5hmC/5fC/caC fold-changes on the gene bodies of up- and downregulated DE genes (c). P values were calculated by the Wilcoxon rank-sum test (P < 0.05 (*); P < 0.01 (**); P < 0.001 (***); ns, not significant)

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