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Fig. 1 | Clinical Epigenetics

Fig. 1

From: The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease

Fig. 1

Differential gene expression analyses of four brain regions. a Illustration of the 4 studied brain areas, the numbers of differentially expressed (DE) genes in each region (fold-change > 1.5, P value < 0.05), and the top 3 involved KEGG pathways for each group of DE genes. Brain anatomy figures were modified from cases provided courtesy of A.Prof Frank Gaillard (Radiopaedia.org, rID: 47208, 46670). b Venn diagrams showing the overlap of the DE genes in a. c PathView plot shows the PI3K-AKT signaling pathway (KEGG: hsa04151) and relevant genes involved in the FUS (left of gene-box) and HPC (right of gene-box). Color key represents log2 (fold-change) of expression in AD compared to normal controls. d Heatmaps show log2 (fold-changes) of representative brain-region-specific DE genes. The absolute log2 (fold-changes) were sorted from high to low. The top 20 genes were selected. The number in each box is the log2 (fold-change)

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