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Fig. 3 | Clinical Epigenetics

Fig. 3

From: PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation

Fig. 3

DNA methylation in PRDM8 in premature aging syndromes and differential gene expression. a To evaluate aberrant DNA methylation in PRDM8 (at cg27242132) in other premature aging syndromes, we used available DNA methylation profiles of 103 healthy controls (GSE36054, GSE32148, GSE49064), 4 DKC samples (GSE75310), 29 Down syndrome samples (GSE52588), 4 Werner syndrome samples (GSE42865), and 3 Hutchinson-Gilford-Progeria syndrome (HGPS) samples (GSE42865). DNA methylation levels (β values) revealed hypermethylation in all premature aging syndromes. t test: * P < 0.05, ** P < 0.01, *** P < 0.001. bd Expression of all PRDM8 transcripts (b), the long PRDM8 transcript (NM020026.3; c), and the short transcript (NM001099403.2; d) was analyzed by qRT-PCR in 10 controls, 27 AA, and 14 DKC patients. t test: * P < 0.05; ns, not significant

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