Fig. 1

Telomere age and epigenetic age are increased in dyskeratosis congenita and aplastic anemia. a Telomere lengths of 105 healthy donors [17], 65 aplastic anemia (AA), and 17 dyskeratosis congenita (DKC) patients were measured in granulocytes and correlated to chronological age. DKC and AA patients show a reduced telomere length compared to healthy controls. b Offset of predicted telomere age (delta age) was higher for DKC and AA patients than for healthy controls [17]. t test: *** P < 0.001, **** P < 0.0001. c Epigenetic age predictions of 70 AA and 18 DKC samples revealed much lower correlation to chronological age than 243 healthy controls [17, 25]. d The difference between predicted epigenetic age and chronological age (delta age) was higher for DKC and AA than for healthy controls, as described for other samples before [17]. t test: ** P < 0.01, **** P < 0.0001. e, f Telomere age and epigenetic age (e), as well as delta telomere age and delta epigenetic age (f), do not correlate in 62 AA and 13 DKC samples