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Table 3 Top 20 DMCs within the promoter region

From: Genome-wide profiling of DNA methylation and gene expression identifies candidate genes for human diabetic neuropathy

Gene

CpG location

q value

Methylation difference (%)

Type

Gene description

DOK7

chr4:3486002

2.17E−38

−50.10

Protein_coding

Docking protein 7

MIR3648-1

chr21:9825780

1.02E−20

−30.84

MicroRNA

MicroRNA 3648-1

GALNT9

chr12:132692165

2.53E−33

28.53

Protein_coding

Polypeptide N-acetylgalactosaminyltransferase 9

C15orf57

chr15:40858818

5.12E−24

28.46

Protein_coding

Chromosome 15 open reading frame 57

TNNT3

chr11:1939527

5.15E−08

−28.28

Protein_coding

Troponin T type 3 (skeletal, fast)

P2RX1

chr17:3821014

4.19E−34

−27.10

Protein_coding

Purinergic receptor P2X, ligand-gated ion channel, 1

LMF1

chr16:1022800

2.21E−11

−26.96

Protein_coding

Lipase maturation factor 1

VAC14-AS1

chr16:70787597

7.18E−07

−26.42

Antisense

VAC14 antisense RNA 1

HOXA-AS3

chr7:27179251

4.33E−06

−25.87

Antisense

HOXA cluster antisense RNA 3

LOC100129931

chr4:7048841

1.02E−58

25.30

ncRNA

Uncharacterized LOC100129931

LINC01168

chr10:134778467

1.01E−13

−25.27

LincRNA

Long intergenic non-protein coding RNA 1168

SNORD59B

chr12:57038157

1.58E−05

24.49

snoRNA

Small nucleolar RNA, C/D box 59B

SNAI3

chr16:88753392

5.22E−06

−24.27

Protein_coding

Snail homolog 3 (Drosophila)

MIR3648-1

chr21:9825613

1.59E−33

24.04

MicroRNA

MicroRNA 3648-1

MIR3687-1

chr21:9826027

2.08E−17

−24.02

MicroRNA

MicroRNA 3687-1

LOC100134317

chr19:36800758

5.25E−20

23.97

ncRNA

Uncharacterized LOC100134317

MIR663AHG

chr20:26189971

1.66E−07

23.77

MicroRNA

MIR663A host gene

AEBP2

chr12:19592255

2.69E−07

23.69

Protein_coding

AE binding protein 2

CABLES1

chr18:20712894

1.01E−05

23.43

Protein_coding

Cdk5 and Abl enzyme substrate 1

GBP5

chr1:89739007

1.41E−35

22.80

Protein_coding

Guanylate binding protein 5