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Table 1 Modules of co-expressed genes and their intramodular hubs

From: Gene co-expression and histone modification signatures are associated with melanoma progression, epithelial-to-mesenchymal transition, and metastasis

Module Number of genes Module-trait relationships (p < 0.1 and correlation > ± 0.5) Intramodular hubs (top 10 Kwithin values)
Turquoise 944 EMT and metastasis Slit3, Lrfn3, Gm29100, Ankfn1, Cxcl14, H2-DMb1, Unc5c, Loxl1, Nid2, Prrx2
Blue 721 Tumor, progression, and metastasis Sec13, Cmas, Kmt2a, Sco1, Manf, Mrpl55, Golt1b, Thoc3, Cdc34, Cox10
Yellow 509 EMT and metastasis Prelid1, Snx3, Ppip5k1, Kremen1, Ttyh2, Pla2g12a, Ost4, Kat8, Snd1, Mvb12b
Red 295 Tumor, progression, and EMT Abhd10, Lrch3, Robo1, Ubl4a, Prim2, Hmces, 4933423P22Rik, Slc2a4, Dlg1, Pdzd11
Black 293 Progression and metastasis Prex1, Map2k4, Eepd1, Psma3, Fam131c, Cc2d1b, Prkx, Mbtps1, Tpk1, Neto2
Magenta 149 EMT and metastasis Dnajc8, Cars2, Pank4, Edem1, Sap30, Mutyh, Usp28, Adi1, Zbtb16, Gbe1
Purple 130 Tumor Gpat4, Pithd1, Pex14, A430005L14Rik, Dgat2, Mtfr1l, Psmb2, Rps6, Brf2, Coprs
Green yellow 122 EMT and metastasis Gyg, Hgsnat, Rnf41, Psen2, Mapkapk3, BC031181, Vat1, Gab2, Traf4, Supt16
Tan 119 EMT Kif4, Sra1, Tmem38a, Aco2, Coq10b, Klhl15, Mapre1, Mark4, 1500011B03Rik, Mttp
Salmon 118 EMT Pcdhb18, Scube3, Pkib, Mid2, Gpa33, Bicd1, Gfra1, Col9a1, Ssc5d, Ctnnal1
Midnight blue 109 EMT and metastasis Trabd2b, Ccdc88c, Mdm1, Bace2, M6pr, Pla2g7, Ube2t, Cdh5, Agl, Flt1
Light cyan 85 Progression and metastasis N4bp1, Mks1, Irak1bp1, Wdr41, Keap1, Tgfbrap1, Extl2, Commd3, Osbpl9, Gba2
Pink 178 Progression Arhgap12, Mad2l1bp, Nfkbil1, Zfp397, Plpp1, Mgat1, Bag3, Zfp653, Surf4, Cog1
Brown 519 No relationship Yme1l1, Psmc6, Ranbp2, Nol8, Fam208b, Ap4e1, Prpf4b, Uba6, Ckap5, Bod1l
  1. Hubs were defined as the top 10 ranked genes in each module based on Kwithin values. Module-trait relationships were considered to be significant if the p value < 0.1 and the correlation ≥ 0.5