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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Gene co-expression and histone modification signatures are associated with melanoma progression, epithelial-to-mesenchymal transition, and metastasis

Fig. 2

Relationship between the expression of genes in specific modules and overall survival in human melanoma patients from the TCGA melanoma cohort. The search for the prognostic value of genes in specific modules was performed using TCGA (The Cancer Genome Atlas) data for skin cutaneous melanoma (SKCM). Kaplan-Meier curves were built using overall survival in months as the clinical outcome and separating samples into two groups based on the median values for each gene (high and low expression groups). a Heatmaps showing the hazard ratios in logarithmic scale (log10) for different genes from the turquoise module. The red and blue blocks indicate higher and lower risks, respectively. The turquoise module had a significant enrichment (p = 0.009) of melanoma prognostic genes (500 top-ranked prognostic genes by p value) identified using the TCGA SKCM data. b Kaplan–Meier survival plots showing the prognostic value of the genes Oca2, Samhd1, Nlrc5, and Dram1 from the turquoise module in skin cell melanoma samples from TCGA. Oca2 showed a significant negative prognostic value in melanoma (i.e., higher expression was associated with worst prognosis), whereas Samhd1, Nlrc5, and Dram1 had a positive prognostic impact. c Ten-gene hub signature from the green yellow module shows significant prognostic value (HR = 1.5, p value = 0.002) in human melanoma. The hub genes Gab2, Vat1, Mapkapk3, and Psen2 also showed individual significant prognostic values. d Ten-gene hub signature from the yellow module shows significant prognostic value (HR = 1.5, p value = 0.002) in human melanoma. The hub genes Ttyh2 and Prelid1 also showed individual significant prognostic impact in melanoma. Genes or gene signatures with log-rank p values less than 0.05 were considered to have statistically significant prognostic value. The cox proportional hazard ratios and 95% confidence intervals were also included in the survival plots

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