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Table 1 Sample characteristics (n = 77)

From: Epigenetic age and pregnancy outcomes: GrimAge acceleration is associated with shorter gestational length and lower birthweight

Variable

Mean ± SD or % (N)

Range

Age (years)

33.1 ± 4.81

22.0–45.0

Marital status (married)

87% (65)

 

Per Capita Household income ($1000)

52.5 ± 40.3

2.83–200

Education (years)

16.9 ± 2.90

12.0–26.0

Race/ethnicity

 White

49% (38)

 

 Black

10% (8)

 

 Latina

23% (18)

 

 Asian

12% (9)

 

 Multi-race

5% (4)

 

Smoking (yes)

0% (0)

 

Pre-pregnancy BMI

25.0 ± 5.82

16.8–36.4

Parity (primiparous)

61% (47)

 

GA at first assessment (weeks)

15.6 ± 2.15

12.0–24.4

GA at birth (weeks)

39.4 ± 1.47

32.9–42.0

Birthweight (g)

3371 ± 507

1086–4624

Age acceleration residual

.135 ± 3.79

− 9.03–12.6

Senescence T cells

.643 ± 2.68

− 5.98–10.4

IEAA

.252 ± 3.63

− .973–13.3

EEAA

.702 ± 4.15

− 16.1–9.27

PEAA

32.5 ± 6.44

17.8–58.2

GrimAgeAccel

.500 ± 3.17

− 5.59–11.3

DNAm PAI-1

19.8 ± 2176

− 5578–5777

DNAm ADM

1.17 ± 14.1

− 34.6–43.8

DNAm B2M

8541 ± 77,648

− 138,633–326,766

DNAm cystatin C

2728 ± 20,284

− 32,366–74,727

DNAm GDF

4.41 ± 84.3

− 118–527

DNAm leptin

−55.2 ± 1584

− 3448–3296

DNAm TIMP1

135 ± 564

− 932–1632

DNAm smoking pack years

.076 ± 6.80

− 11.3–27.4

DNAm TL

− .008 ± .162

− .399–.424

  1. ADM adrenomedullin, B2M β2 Microglobulin, BMI body mass index, EEAA extrinsic epigenetic age acceleration, IEAA intrinsic epigenetic age acceleration, GA gestational age, GDF growth and differentiation factor, GrimAgeAccel GrimAge acceleration, PAI-1 plasminogen activation inhibitor-1, PEAA phenotypic epigenetic age acceleration, TIMP-1 tissue inhibitor of metalloproteinases-1, TL telomere