Table 2 Multiple linear regression analysis showing the association of smoking and PM2.5 with AHRR cg05575921 methylation in the study participants
From: AHRR cg05575921 methylation in relation to smoking and PM2.5 exposure among Taiwanese men and women
Variable | Model 1 | Model 2 | ||
|---|---|---|---|---|
β | P value | β | P value | |
Smoking status (reference: never) | ||||
 Former | − 0.03909 | < 0.0001 | − 0.02221 | < 0.0001 |
 Current | − 0.17536 | < 0.0001 | − 0.11578 | < 0.0001 |
 P-trend | < 0.0001 | < 0.0001 | ||
PM2.5 | − 0.00141 | < 0.0001 | − 0.00070 | 0.0120 |
Sex (reference: women) | ||||
 Men | − 0.01870 | < 0.0001 | − 0.01843 | < 0.0001 |
Age | − 0.00044 | 0.0145 | − 0.00018 | 0.2636 |
Exercise (reference: no) | ||||
 Yes | 0.00077 | 0.8404 | 0.00052 | 0.8772 |
BMI | 0.00060 | 0.2344 | 0.00014 | 0.7488 |
Alcohol drinking (reference: no) | ||||
 Former | − 0.00512 | 0.5931 | − 0.00821 | 0.3264 |
 Current | 0.00157 | 0.8318 | 0.00539 | 0.4041 |
Secondhand smoke (reference: no) | ||||
 Yes | 0.00136 | 0.8100 | − 0.00204 | 0.6793 |
F2LR3 cg03636183 methylation | – | – | 0.71185 | < 0.0001 |