From: Genome-wide methylation patterns predict clinical benefit of immunotherapy in lung cancer
Probe | Coefficient | Gene symbol | Gene function | Cancer relatedness |
---|---|---|---|---|
cg22029157 | − 1.52 | IRF6 | Interferon regulatory factor associated with cytokine signaling | Tumor suppressor activity |
cg12007048 | − 1.096 | CTSD | Proteolytic activation of hormones and growth factors (i.e., EGFR) | Linked with poor prognosis in NSCLC |
cg07935119 | − 1.04 | GRN | Granulin coding gene; growth factor involved in inflammation and cell proliferation | Regulate tumorigenesis; immune evasion, proliferation |
cg23079808 | − 0.989 | LTBR | Tumor necrosis factor receptor; signaling immune response and programmed cell death | Activation linked to carcinogenesis |
cg04450862 | − 0.907 | TRIM36 | Mediate ubiquitination and proteasomal degradation of target protein | Known to be upregulated in cancer |
cg19918549 | 0.347 | EVL | Actin-associated proteins involved in axon guidance | Upregulated in breast cancer |
cg24612198 | 0.385 | CD3E | Part of CD3 complex that facilitate T cell development | Down regulation of this gene results in T cell apoptosis |
cg17771150 | 0.969 | LCP1 | Actin-binding protein that are involved in T cell activation | Upregulated in cancer |