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Table 1 Genes used in methylation-based prognostic prediction model

From: Genome-wide methylation patterns predict clinical benefit of immunotherapy in lung cancer

Probe

Coefficient

Gene symbol

Gene function

Cancer relatedness

cg22029157

− 1.52

IRF6

Interferon regulatory factor associated with cytokine signaling

Tumor suppressor activity

cg12007048

− 1.096

CTSD

Proteolytic activation of hormones and growth factors (i.e., EGFR)

Linked with poor prognosis in NSCLC

cg07935119

− 1.04

GRN

Granulin coding gene; growth factor involved in inflammation and cell proliferation

Regulate tumorigenesis; immune evasion, proliferation

cg23079808

− 0.989

LTBR

Tumor necrosis factor receptor; signaling immune response and programmed cell death

Activation linked to carcinogenesis

cg04450862

− 0.907

TRIM36

Mediate ubiquitination and proteasomal degradation of target protein

Known to be upregulated in cancer

cg19918549

0.347

EVL

Actin-associated proteins involved in axon guidance

Upregulated in breast cancer

cg24612198

0.385

CD3E

Part of CD3 complex that facilitate T cell development

Down regulation of this gene results in T cell apoptosis

cg17771150

0.969

LCP1

Actin-binding protein that are involved in T cell activation

Upregulated in cancer