Fig. 4
From: Genome-wide methylation patterns predict clinical benefit of immunotherapy in lung cancer
Mutually exclusive alterations associated with nonresponders’ survival. a–c Representative protein interaction networks showing mutually exclusive hypermethylation patterns. The nodes and edges in the networks represent proteins and interactions, respectively (top right). The colored nodes correspond to genes showing a mutually exclusive promoter hypermethylation pattern. Genes whose promoter is hypermethylated in nonresponders are marked in red (bottom right). Kaplan-Meier survival analyses of the patients are displayed on the right. Patients showing hypermethylation in either or both colored nodes (red) were compared with those without hypermethylation (blue). P values were calculated using the log-rank test