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Table 3 Clinical and anthropometric characteristics of youth obesity and T2D cohorts

From: Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes

 

Lean

OB-NGT

IGT

AAb−

T2D

AAb+

T2D

P value*

Total (% male)

32 (56)

31 (35)

31 (35)

34 (47)

22 (45)

 

Age, years

13 ± 0.2

14 ± 0.3

15 ± 0.4

15 ± 0.3

14 ± 0.5

< 0.001

BMI, Z score (ZS)

-0.14 ± 0.15

2.21 ± 0.10

2.33 ± 0.06

2.39 ± 0.05

1.90 ± 0.12

< 0.001

HbA1c (%)

5.3 ± 0.1

5.4 ± 0.1

5.4 ± 0.1

6.6 ± 0.1

6.3 ± 0.2

< 0.001

Fasting glucose, mg/dL

95.3 ± 3.5

90.8 ± 3.5

92.5 ± 3.5

115.1 ± 3.4

129.1 ± 5.0

< 0.001

2-h OGTT glucose, mg/dL

N/A

111.4 ± 10.5

158.8 ± 8.4

197.5 ± 8.1

299.1 ± 12.1

< 0.001

Treatment modality N (%)

 Lifestyle

   

7 (21)

2 (13)

 

 Insulin

   

4 (12)

3 (19)

 

 Metformin

   

16 (47)

2 (13)

 

 Insulin and metformin

   

7 (21)

9 (56)

 
  1. *P values indicate significance across all cohorts by one-way ANOVA
  2. OB-NGT obese normal glucose tolerance, IGT impaired glucose tolerance, AAb− autoantibody negative, AAb+ autoantibody positiveÂ