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Table 1 Significant and replicated relationships between epigenetic age measures and prevalent disease data, and continuous traits

From: Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden

  Discovery cohort Replication cohort
Categorical phenotypes
Measure Variable n event OR P n event OR P
DNAm GrimAge COPD 48 2.00 1.0 × 10−4 32 3.29 3.4 × 10−4
Continuous phenotypes
Measure Variable n β P n β P
DunedinPoAm Pack Years 2419 0.45 1.2 × 10−112 1340 0.33 7.6 × 10−36
DNAm TL Pack Years 2419 -0.14 1.1 × 10−11 1340 -0.18 2.7 × 10−11
DNAm PhenoAge Pack Years 2419 0.11 3.0 × 10−08 1340 0.16 9.5 × 10−10
DNAm GrimAge SIMD 2419 -0.13 5.9 × 10−08 1340 -0.19 4.6 × 10−09
DNAm GrimAge Average Heart Rate 2416 0.19 1.4 × 10−12 1339 0.20 1.6 × 10−08
DunedinPoAm SIMD 2419 -0.13 1.8 × 10−09 1340 -0.16 2.2 × 10−08
Hannum Age Creatinine 2406 0.21 1.4 × 10−26 1334 0.13 4.2 × 10−07
DNAm GrimAge FEF 2055 -0.12 1.2 × 10−06 1149 -0.15 1.4 × 10−06
DNAm PhenoAge Body Mass Index 2419 0.12 2.5 × 10−10 1340 0.12 7.4 × 10−06
DNAm PhenoAge Average Heart Rate 2416 0.11 2.1 × 10−07 1339 0.12 7.7 × 10−06
DNAm GrimAge FEV 2074 -0.08 2.0 × 10−05 1151 -0.10 1.4 × 10−04
DNAm GrimAge Creatinine 2406 0.19 3.0 × 10−15 1334 0.13 2.0 × 10−04
DunedinPoAm Average Heart Rate 2416 0.19 1.6 × 10−15 1339 0.11 2.2 × 10−04
Mortality analysis
Measure Variable n event HR P n events HR P
DNAm GrimAge All-cause mortality 89 1.62 1.4 × 10−4 30 2.10 5.6 × 10−4
  1. Analyses were performed using a fully adjusted model accounting for age, sex, alcohol consumption, body mass index, deprivation, education and smoking pack years
  2. COPD chronic obstructive pulmonary disease, FEF forced expiratory flow, FEV forced expiratory volume, HR hazard ratio, OR odds ratio, SIMD Scottish Index of Multiple Deprivation, TL telomere length