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Table 1 Significant and replicated relationships between epigenetic age measures and prevalent disease data, and continuous traits

From: Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden

 

Discovery cohort

Replication cohort

Categorical phenotypes

Measure

Variable

n event

OR

P

n event

OR

P

DNAm GrimAge

COPD

48

2.00

1.0 × 10−4

32

3.29

3.4 × 10−4

Continuous phenotypes

Measure

Variable

n

β

P

n

β

P

DunedinPoAm

Pack Years

2419

0.45

1.2 × 10−112

1340

0.33

7.6 × 10−36

DNAm TL

Pack Years

2419

-0.14

1.1 × 10−11

1340

-0.18

2.7 × 10−11

DNAm PhenoAge

Pack Years

2419

0.11

3.0 × 10−08

1340

0.16

9.5 × 10−10

DNAm GrimAge

SIMD

2419

-0.13

5.9 × 10−08

1340

-0.19

4.6 × 10−09

DNAm GrimAge

Average Heart Rate

2416

0.19

1.4 × 10−12

1339

0.20

1.6 × 10−08

DunedinPoAm

SIMD

2419

-0.13

1.8 × 10−09

1340

-0.16

2.2 × 10−08

Hannum Age

Creatinine

2406

0.21

1.4 × 10−26

1334

0.13

4.2 × 10−07

DNAm GrimAge

FEF

2055

-0.12

1.2 × 10−06

1149

-0.15

1.4 × 10−06

DNAm PhenoAge

Body Mass Index

2419

0.12

2.5 × 10−10

1340

0.12

7.4 × 10−06

DNAm PhenoAge

Average Heart Rate

2416

0.11

2.1 × 10−07

1339

0.12

7.7 × 10−06

DNAm GrimAge

FEV

2074

-0.08

2.0 × 10−05

1151

-0.10

1.4 × 10−04

DNAm GrimAge

Creatinine

2406

0.19

3.0 × 10−15

1334

0.13

2.0 × 10−04

DunedinPoAm

Average Heart Rate

2416

0.19

1.6 × 10−15

1339

0.11

2.2 × 10−04

Mortality analysis

Measure

Variable

n event

HR

P

n events

HR

P

DNAm GrimAge

All-cause mortality

89

1.62

1.4 × 10−4

30

2.10

5.6 × 10−4

  1. Analyses were performed using a fully adjusted model accounting for age, sex, alcohol consumption, body mass index, deprivation, education and smoking pack years
  2. COPD chronic obstructive pulmonary disease, FEF forced expiratory flow, FEV forced expiratory volume, HR hazard ratio, OR odds ratio, SIMD Scottish Index of Multiple Deprivation, TL telomere length