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Table 5 Overall and stage-wise performance of methylation panels in stool for detection of colorectal neoplasms

From: Fecal DNA methylation markers for detecting stages of colorectal cancer and its precursors: a systematic review

Gene panel

First author, year, Ref. No.

Country

Study group

No.

DNA methylation assay

Sn (%)

CRC stage

No.

Stage-specific Sn (%)

Sp (%)

MGMT, MLH1, and VIM (promoters)

Baek, 2009 [44]

South Korea

NAA

AA

Ad

CRC

Cn

30

22

52

60

37

MSP

70

46

60

75

I/II

III/IV

35

25

71

80

87

ITGA4, SFRP2, and CDKN2A (promoters)

Chang, 2010 [46]

Korea

NAA

AA

Ad

CRC

Cn

17

8

25

30

31

MSP

65

88

72

70

I/II

III/IV

14

16

64

75

97

SFRP2, GATA4/5, NDRG4 and VIM (promoters)

Lu, 2014 [49]

China

CRC

Cn

56

40

MSP

96

I/II

III/IV

32

24

94

100

65

SFRP2 and WIF-1 (promoters)

Zhang, 2014 [50]

China

NAA

AA

Ad

CRC

Cn

20

15

35

48

30

MSP

55

80

66

81

I/A

II/B

III/C

IV/D

7

20

14

7

86

80

71

100

97

SFRP2, TFPI2, NDRG4, and BMP3 (promoters)

Park, 2017 [34]

South Korea

AA

CRC

Cn

36

35

40

MSP

72

94

I/II

III/IV

17

18

88

100

55

COL4A2 and TLX2 (promoter/exon 1)

Liu, 2019 [40]

China

AA

CRC

Cn

77

80

83

qMSP

52

91

I/II

III/IV

43

37

86

97

98

  1. Note: Stages I/II/III/IV as per UICC classification and stages A/B/C/D as per Dukes classification
  2. Ref. reference, No. number, Sn sensitivity, Sp specificity, MSP methylation-specific polymerase chain reaction, qMSP quantitative methylation-specific real-time polymerase chain reaction, NAA non-advanced adenoma, AA advanced adenoma, Ad adenoma, Cn Control