Gene panel | First author, year, Ref. No. | Country | Study group | No. | DNA methylation assay | Sn (%) | CRC stage | No. | Stage-specific Sn (%) | Sp (%) |
---|---|---|---|---|---|---|---|---|---|---|
MGMT, MLH1, and VIM (promoters) | Baek, 2009 [44] | South Korea | NAA AA Ad CRC Cn | 30 22 52 60 37 | MSP | 70 46 60 75 | I/II III/IV | 35 25 | 71 80 | 87 |
ITGA4, SFRP2, and CDKN2A (promoters) | Chang, 2010 [46] | Korea | NAA AA Ad CRC Cn | 17 8 25 30 31 | MSP | 65 88 72 70 | I/II III/IV | 14 16 | 64 75 | 97 |
SFRP2, GATA4/5, NDRG4 and VIM (promoters) | Lu, 2014 [49] | China | CRC Cn | 56 40 | MSP | 96 | I/II III/IV | 32 24 | 94 100 | 65 |
SFRP2 and WIF-1 (promoters) | Zhang, 2014 [50] | China | NAA AA Ad CRC Cn | 20 15 35 48 30 | MSP | 55 80 66 81 | I/A II/B III/C IV/D | 7 20 14 7 | 86 80 71 100 | 97 |
SFRP2, TFPI2, NDRG4, and BMP3 (promoters) | Park, 2017 [34] | South Korea | AA CRC Cn | 36 35 40 | MSP | 72 94 | I/II III/IV | 17 18 | 88 100 | 55 |
COL4A2 and TLX2 (promoter/exon 1) | Liu, 2019 [40] | China | AA CRC Cn | 77 80 83 | qMSP | 52 91 | I/II III/IV | 43 37 | 86 97 | 98 |