Skip to main content

Table 5 Overall and stage-wise performance of methylation panels in stool for detection of colorectal neoplasms

From: Fecal DNA methylation markers for detecting stages of colorectal cancer and its precursors: a systematic review

Gene panel First author, year, Ref. No. Country Study group No. DNA methylation assay Sn (%) CRC stage No. Stage-specific Sn (%) Sp (%)
MGMT, MLH1, and VIM (promoters) Baek, 2009 [44] South Korea NAA
AA
Ad
CRC
Cn
30
22
52
60
37
MSP 70
46
60
75
I/II
III/IV
35
25
71
80
87
ITGA4, SFRP2, and CDKN2A (promoters) Chang, 2010 [46] Korea NAA
AA
Ad
CRC
Cn
17
8
25
30
31
MSP 65
88
72
70
I/II
III/IV
14
16
64
75
97
SFRP2, GATA4/5, NDRG4 and VIM (promoters) Lu, 2014 [49] China CRC
Cn
56
40
MSP 96 I/II
III/IV
32
24
94
100
65
SFRP2 and WIF-1 (promoters) Zhang, 2014 [50] China NAA
AA
Ad
CRC
Cn
20
15
35
48
30
MSP 55
80
66
81
I/A
II/B
III/C
IV/D
7
20
14
7
86
80
71
100
97
SFRP2, TFPI2, NDRG4, and BMP3 (promoters) Park, 2017 [34] South Korea AA
CRC
Cn
36
35
40
MSP 72
94
I/II
III/IV
17
18
88
100
55
COL4A2 and TLX2 (promoter/exon 1) Liu, 2019 [40] China AA
CRC
Cn
77
80
83
qMSP 52
91
I/II
III/IV
43
37
86
97
98
  1. Note: Stages I/II/III/IV as per UICC classification and stages A/B/C/D as per Dukes classification
  2. Ref. reference, No. number, Sn sensitivity, Sp specificity, MSP methylation-specific polymerase chain reaction, qMSP quantitative methylation-specific real-time polymerase chain reaction, NAA non-advanced adenoma, AA advanced adenoma, Ad adenoma, Cn Control