Fig. 1

Trajectories of serum CRP and the DNAm CRP score over age. a Observed trajectories in the Lothian Birth Cohort 1936. Grey lines represent individual participant trajectories with regression lines shown for females and males in blue and purple, respectively. b Latent trajectories in Lothian Birth Cohort 1936. Latent classes are shown in red (class 1) and blue (class 2). c Pseudo-trajectories in Generation Scotland for CRP (n = 419) and the DNAm CRP score (n = 7028). Regression lines are as in (a). Black lines represent density. DNAm = DNA methylation; CRP = C-reactive protein