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Table 2 Subgroup analysis of methylation with and without IUGR and HDP

From: IGF1 gene is epigenetically activated in preterm infants with intrauterine growth restriction

  CG108 CG137 CG207 CG218 CG224 CG232
HDP (−) median 0.70 0.75 0.51 0.71 0.68 0.72
  25% 0.64 0.67 0.44 0.63 0.61 0.65
  75% 0.74 0.78 0.55 0.76 0.75 0.79
HDP (+) median 0.65 0.69 0.46 0.69 0.65 0.71
  25% 0.57 0.59 0.42 0.63 0.58 0.62
  75% 0.70 0.76 0.53 0.75 0.70 0.76
p value 0.13 0.17 0.27 0.76 0.33 0.61
IUGR (−) HDP(-)  median 0.71 0.77 0.52 0.72 0.71 0.74
  25% 0.65 0.70 0.46 0.65 0.64 0.67
  75% 0.75 0.80 0.55 0.76 0.76 0.79
IUGR (−)   HDP(+)        median 0.71 0.77 0.53 0.75 0.70 0.76
  25% 0.55 0.63 0.40 0.58 0.57 0.60
  75% 0.76 0.84 0.63 0.83 0.80 0.83
p value 0.98 0.86 0.90 0.60 0.90 0.82
IUGR (+)   HDP(-)          median 0.59 0.67 0.44 0.64 0.63 0.68
  25% 0.52 0.50 0.36 0.56 0.53 0.56
  75% 0.69 0.74 0.52 0.71 0.68 0.71
IUGR (+) HDP(+)         median 0.63 0.67 0.45 0.67 0.65 0.69
  25% 0.57 0.59 0.42 0.63 0.58 0.62
  75% 0.67 0.72 0.49 0.72 0.68 0.74
p value 0.86 1.00 0.86 0.55 0.70 0.60
  1. The methylation of each CpG site in infant subgroups is shown as median, 25%, 75%. p was calculated by Mann-Whitney U test
  2. HDP: Hypertensive disorders of pregnancy