IGF1 gene is epigenetically activated in preterm infants with intrauterine growth restriction

Clinical Epigenetics

Table 2 Subgroup analysis of methylation with and without IUGR and HDP

		CG108	CG137	CG207	CG218	CG224	CG232
HDP (−) median		0.70	0.75	0.51	0.71	0.68	0.72
	25%	0.64	0.67	0.44	0.63	0.61	0.65
	75%	0.74	0.78	0.55	0.76	0.75	0.79
HDP (+) median		0.65	0.69	0.46	0.69	0.65	0.71
	25%	0.57	0.59	0.42	0.63	0.58	0.62
	75%	0.70	0.76	0.53	0.75	0.70	0.76
p value		0.13	0.17	0.27	0.76	0.33	0.61
IUGR (−) HDP(-) median		0.71	0.77	0.52	0.72	0.71	0.74
	25%	0.65	0.70	0.46	0.65	0.64	0.67
	75%	0.75	0.80	0.55	0.76	0.76	0.79
IUGR (−) HDP(+) median		0.71	0.77	0.53	0.75	0.70	0.76
	25%	0.55	0.63	0.40	0.58	0.57	0.60
	75%	0.76	0.84	0.63	0.83	0.80	0.83
p value		0.98	0.86	0.90	0.60	0.90	0.82
IUGR (+) HDP(-) median		0.59	0.67	0.44	0.64	0.63	0.68
	25%	0.52	0.50	0.36	0.56	0.53	0.56
	75%	0.69	0.74	0.52	0.71	0.68	0.71
IUGR (+) HDP(+) median		0.63	0.67	0.45	0.67	0.65	0.69
	25%	0.57	0.59	0.42	0.63	0.58	0.62
	75%	0.67	0.72	0.49	0.72	0.68	0.74
p value		0.86	1.00	0.86	0.55	0.70	0.60

The methylation of each CpG site in infant subgroups is shown as median, 25%, 75%. p was calculated by Mann-Whitney U test
HDP: Hypertensive disorders of pregnancy

ISSN: 1868-7083