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Table 2 Pathway enrichment results for genes associated with the top 300 key probes belonging to the skin-specific DNAm age predictor. The top 10 results are shown. The enrichment method ORA was performed using the KEGG database. P values were corrected to control for FDR using the Bonferroni method, statistically significant enrichment is highlighted in bold letters

From: Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging

Description

Enrichment ratio

p value

FDR

Genes

cAMP signaling pathway

5.7451

2.1 × 10−5

6.7 × 10−3

ACOX3; CACNA1C; CNGA3; GHSR; GRIA2; GRIN2D; HTR1E; PDE4C; RYR2

Neuroactive ligand-receptor interaction

4.2918

2.0 × 10−4

3.2 × 10−2

AVPR1A; CRHR1; GHSR; GRIA2; GRIN2D; HTR1E; LEP; PRLHR; PTGFR

Circadian entrainment

6.4865

9.6 × 10−4

0.104

CACNA1C; CACNA1G; GRIA2; GRIN2D; RYR2

Cardiac muscle contraction

7.0969

2.3 × 10−3

0.151

CACNA1C; CACNG7; COX5A; RYR2

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

6.9941

2.4 × 10−3

0.151

ACTN2; CACNA1C; CACNG7; RYR2

Calcium signaling pathway

4.2087

2.8 × 10−3

0.151

AVPR1A; CACNA1C; CACNA1G; GRIN2D; PTGFR; RYR2

GABAergic synapse

5.8144

4.8 × 10−3

0.220

ABAT; CACNA1C; GAD1; SLC12A5

Type II diabetes mellitus

8.226

5.6 × 10−3

0.226

CACNA1C; CACNA1G; IRS2

Amyotrophic lateral sclerosis (ALS)

7.0969

8.4 × 10−3

0.303

GRIA2; GRIN2D; NEFM

Alcoholism

3.7009

1.1 × 10−2

0.350

GRIN2D; H2AFY; HIST1H2AI; HIST1H2BK; HIST1H4I