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Table 2 Pathway enrichment results for genes associated with the top 300 key probes belonging to the skin-specific DNAm age predictor. The top 10 results are shown. The enrichment method ORA was performed using the KEGG database. P values were corrected to control for FDR using the Bonferroni method, statistically significant enrichment is highlighted in bold letters

From: Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging

Description Enrichment ratio p value FDR Genes
cAMP signaling pathway 5.7451 2.1 × 105 6.7 × 103 ACOX3; CACNA1C; CNGA3; GHSR; GRIA2; GRIN2D; HTR1E; PDE4C; RYR2
Neuroactive ligand-receptor interaction 4.2918 2.0 × 104 3.2 × 102 AVPR1A; CRHR1; GHSR; GRIA2; GRIN2D; HTR1E; LEP; PRLHR; PTGFR
Circadian entrainment 6.4865 9.6 × 10−4 0.104 CACNA1C; CACNA1G; GRIA2; GRIN2D; RYR2
Cardiac muscle contraction 7.0969 2.3 × 10−3 0.151 CACNA1C; CACNG7; COX5A; RYR2
Arrhythmogenic right ventricular cardiomyopathy (ARVC) 6.9941 2.4 × 10−3 0.151 ACTN2; CACNA1C; CACNG7; RYR2
Calcium signaling pathway 4.2087 2.8 × 10−3 0.151 AVPR1A; CACNA1C; CACNA1G; GRIN2D; PTGFR; RYR2
GABAergic synapse 5.8144 4.8 × 10−3 0.220 ABAT; CACNA1C; GAD1; SLC12A5
Type II diabetes mellitus 8.226 5.6 × 10−3 0.226 CACNA1C; CACNA1G; IRS2
Amyotrophic lateral sclerosis (ALS) 7.0969 8.4 × 10−3 0.303 GRIA2; GRIN2D; NEFM
Alcoholism 3.7009 1.1 × 10−2 0.350 GRIN2D; H2AFY; HIST1H2AI; HIST1H2BK; HIST1H4I