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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging

Fig. 6

Effect of senotherapeutic treatments in human skin biopsies treated with 100 nM Rapamycin for 5 days. a Predicted DNAm age using the skin-specific molecular clock. b Representative images of H&E of treated and untreated (control) samples, c mRNA expression in the epidermis, and d mRNA expression in the dermis. Ctrl control, IGFBP3 insulin growth factor binding protein 3, B2M β2 microglobulin, IL8 interleukin-8, HAS2 hyaluronic acid synthase 2, COL1A1 collagen type 1 alpha 1 compared to untreated samples using ANOVA and Bonferroni, or t test. Data refer to experiments performed in triplicate

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Clinical Epigenetics

ISSN: 1868-7083

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