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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging

Fig. 3

Importance of predictors. a Variable importance for top 50 predictors according to the Loess r-squared variable importance given by the varImp function from caret R package. b Frequency of regions where top 50 probes are located. Blue color refers to probes positively correlated with age in the model, and red color refers to probes negatively correlated with age. c Heat map of DNA methylation levels of the top 50 probes. Color codes represent beta DNAm values after row-wise z-score transformation. Probes (rows) are ordered according to their importance. Samples were ordered according to their age. d Heat map of the top 50 CpG-related gene expression levels associated with the model across all samples. Only genes with SD higher than the second quartile are plotted. Color-codes represent log(normalized expression +‚ÄČ1) values after row-wise z-score transformation. Genes (rows) were clustered using Pearson correlation. Samples were ordered according to their age. Features regarding tissue of origin, sun exposure, sex, and aging group (age 1: under 30 years old, age 2: between 30 and 60 years old and age 3: over 60 years old) are also shown

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